75000 - Document - Document and Entity Information
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75010 - Statement - BALANCE SHEETS
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75020 - Statement - BALANCE SHEETS (Parenthetical)
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75030 - Statement - STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
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75040 - Statement - STATEMENTS OF STOCKHOLDERS' EQUITY
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75050 - Statement - STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical)
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75060 - Statement - STATEMENTS OF CASH FLOWS
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75070 - Statement - STATEMENTS OF CASH FLOWS 2
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995457 - Disclosure - Cybersecurity Risk Management, Strategy and Governance
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995467 - Disclosure - Organization and Principal Activities
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995477 - Disclosure - Summary of Significant Accounting Policies
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995487 - Disclosure - Fair Value Measurements
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995497 - Disclosure - Balance Sheet Components
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995507 - Disclosure - Leases
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995517 - Disclosure - SVB Term Loan
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995527 - Disclosure - Commitments and Contingencies
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995537 - Disclosure - License and Purchase Agreements
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995547 - Disclosure - Capital Structure
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995557 - Disclosure - Stock-Based Compensation
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995567 - Disclosure - Income Taxes
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995577 - Disclosure - 401(k) Retirement Savings Plan
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995587 - Disclosure - Net Loss Per Share
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995597 - Disclosure - Related Party Transactions
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995607 - Disclosure - Subsequent Events
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995617 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995627 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995637 - Disclosure - Fair Value Measurements (Tables)
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995647 - Disclosure - Balance Sheet Components (Tables)
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995657 - Disclosure - Leases (Tables)
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995667 - Disclosure - Capital Structure (Tables)
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995677 - Disclosure - Stock-Based Compensation (Tables)
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995687 - Disclosure - Income Taxes (Tables)
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995697 - Disclosure - Net Loss Per Share (Tables)
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995707 - Disclosure - Organization and Principal Activities - Additional Information (Details)
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995717 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
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995727 - Disclosure - Summary of Significant Accounting Policies - Schedule of Useful Lives of Property and Equipment (Details)
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995737 - Disclosure - Fair Value Measurements - Summary of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)
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995747 - Disclosure - Fair Value Measurements - Additional Information (Details)
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995757 - Disclosure - Fair Value Measurements - Schedule of Pre-funded Warrants Measured Using Black-Scholes Option Pricing Model (Details)
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995767 - Disclosure - Fair Value Measurements - Schedule of Aggregate Fair Value of Warrant Liability (Details)
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995777 - Disclosure - Fair Value Measurements - Summary of Investments in an Unrealized Loss Position (Details)
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995787 - Disclosure - Fair Value Measurements - Summary of Investments in an Unrealized Loss Position (Details) 2
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995797 - Disclosure - Balance Sheet Components - Schedule of Accrued Expenses and Other Current Liabilities (Details)
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995807 - Disclosure - Leases - Additional Information (Details)
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995817 - Disclosure - Leases - Other information related to operating leases (Details)
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995827 - Disclosure - Leases - Future Minimum Annual Lease Commitments under Non-cancelable Operating Leases (Detail)
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995837 - Disclosure - Leases - Future Minimum Annual Lease Commitments under Non-cancelable Operating Leases (Detail) 2
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995847 - Disclosure - SVB Term Loan - Additional Information (Details)
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995857 - Disclosure - License and Purchase Agreements - Additional Information (Details)
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995867 - Disclosure - Commitments and Contingencies - Additional Information (Details)
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995877 - Disclosure - Capital Structure - Additional Information (Details)
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995887 - Disclosure - Capital Structure - Summary of Common Stock Reserved for Future Issuance (Details)
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995897 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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995907 - Disclosure - Stock-Based Compensation - Summary of Stock Option Activity - 2020 Equity Incentive Plan (Details)
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995917 - Disclosure - Stock-Based Compensation - Summary of RSU Activity (Details)
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995927 - Disclosure - Stock-Based Compensation - Schedule of Weighted-Average Assumptions to Estimate Fair Value of Stock Options and Purchase Rights Under ESPP Using the Black-Scholes Option-Pricing Model (Details)
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995937 - Disclosure - Stock-Based Compensation - Summary of Stock-Based Compensation Expense Related to Stock Options, RSUs and ESPP (Details)
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995947 - Disclosure - Income Taxes - Additional Information (Details)
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995957 - Disclosure - Income Taxes - Schedule of Reconciliation of the Federal Statutory Income Tax Rate to Effective Tax Rate (Details)
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995967 - Disclosure - Income Taxes - Schedule of Reconciliation of the Federal Statutory Income Tax Rate to Effective Tax Rate (Details) 2
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995977 - Disclosure - Income Taxes - Schedule of Significant Components of Net Deferred Tax Assets and Liabilities (Details)
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995987 - Disclosure - Income Taxes - Schedule of Significant Components of Net Deferred Tax Assets and Liabilities (Details) 2
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995997 - Disclosure - Income Taxes - Schedule of Reconciliation of Beginning and Ending Balance of Unrecognized Tax Benefits (Details)
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996007 - Disclosure - 401(k) Retirement Savings Plan - Additional Information (Details)
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996017 - Disclosure - Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details)
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996027 - Disclosure - Net Loss Per Share - Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Per Share (Details)
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996037 - Disclosure - Related Party Transactions - Additional Information (Details)
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996047 - Disclosure - Subsequent Events - Additional Information (Details)
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Weighted Average Grant Date Fair Value Per Share, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Software Development [Member]
Computer Software
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Outstanding, Number
Shares, Unvested, Beginning Balance
Shares, Unvested, Ending Balance
Number of RSUs outstanding
Accrued Employee Benefits, Current
Accrued compensation and benefits
Deferred Tax Assets, Gross [Abstract]
Deferred tax assets:
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Preferred Stock, Shares Issued
Preferred stock, shares issued
Preferred Stock, Shares Issued, Total
Accounts payable
Increase (Decrease) in Accounts Payable
Increase (Decrease) in Accounts Payable, Total
Cash Flow, Noncash Investing and Financing Activities Disclosure [Abstract]
Supplemental disclosure of non-cash investing and financing activities:
Long-Term Debt, Excluding Current Maturities
Term loan, net of current portion
Long-term Debt, Excluding Current Maturities, Total
Plan Name [Axis]
Plan Name
Shares subject to outstanding common stock warrants
Shares Subject to Outstanding Common Stock Warrants [Member]
Shares subject to outstanding common stock warrants.
Fair value, twelve months or greater
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer
Debt securities, available-for-sale, Continuous unrealized loss position, 12 months or longer
Equity [Abstract]
Grantee Status [Domain]
Grantee Status
Entity Current Reporting Status
Entity Current Reporting Status
Proceeds from Warrant Exercises
Proceeds from exercise of pre-funded warrants
Operating Expenses [Abstract]
Operating expenses:
Fair Value, Inputs, Level 2 [Member]
Level 2
Deferred Tax Assets, Net of Valuation Allowance
Total deferred tax assets
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Common Stock, Shares Authorized
Common stock, shares authorized
Common stock shares authorized
Share-Based Payment Arrangement, Tranche Three [Member]
Time Based Vesting Installments Through June 30, 2023
Eli Lilly and company.
Eli Lilly And Company [Member]
Eli Lilly and Company [Member]
Reverse Stock Split [Member]
Reverse Stock Split [Member]
Reverse Stock Split
Investments
Investment, Policy [Policy Text Block]
Product and Service [Axis]
Document Fiscal Period Focus
Document Fiscal Period Focus
Accrued Expenses and Other Current Liabilities
Accrued expenses and other current liabilities.
Accrued expenses and other current liabilities
Total accrued expenses and other current liabilities
Interest rate of term loan
Debt Instrument, Interest Rate, Stated Percentage
Tranche Two [Member]
Tranche two
Tranche 2
Entity Shell Company
Entity Shell Company
Grantee Status [Axis]
Grantee Status
Segment Reporting, Policy [Policy Text Block]
Segment Reporting
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalent
Cash and cash equivalents
Cash and cash equivalents
Cash and Cash Equivalents, at Carrying Value, Total
Cash and Cash Equivalents, at Carrying Value, Ending Balance
Weighted Average Number of Shares Outstanding Reconciliation [Abstract]
Denominator:
Non-cash lease expense
Amount of amortization expense for right-of-use asset from leases.
Non Cash Lease Expense
Accrued research and development expenses.
Accrued Research And Development Expenses Policy [Text Block]
Accrued Research and Development Expenses
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Common stock, shares sold and issued
Common Stock, Shares, Issued
Common Stock, Shares, Issued, Total
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
Cybersecurity Risk Board of Directors Oversight [Text Block]
Statement [Table]
Statement [Table]
Restricted cash, long-term (included in other assets)
Restricted Cash, Noncurrent
Increases based on tax positions related to current period
Unrecognized Tax Benefits, Increase Resulting from Current Period Tax Positions
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Right-of-use assets recognized in exchange for lease liabilities
Right-of-use asset recognized in exchange for lease liability
Value of common stock and warrants issued.
Stock Issued During Period Value Of Common Stock And Warrants
Issuance of common stock, net of offering costs
Percentage of outstanding shares subject to automatic increase in common stock.
Percentage Of Outstanding Shares Subject To Automatic Increase In Common Stock
Percentage of outstanding shares subject to automatic increase in common stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average fair value of options granted
Payments to Acquire Businesses, Gross
Consideration paid
Share-Based Compensation Arrangement by Share-Based Payment Award, Purchase Price of Common Stock, Percent
Purchase price of common stock expressed as a percentage of fair market value
Income Tax Reconciliation Nondeductible Expense Loss on Fair Value of Warrant Liability
Income Tax Reconciliation Nondeductible Expense Loss on Fair Value of Warrant Liability
Loss on fair value of warrant liability
Threshold percentage of tax positions likely of being realized upon ultimate settlement.
Threshold Percentage Of Tax Positions Likely Of Being Realized Upon Ultimate Settlement
Percentage of tax positions likely of being realized upon ultimate settlement
Statement [Line Items]
Statement [Line Items]
2026 Warrant
Common Stock Warrant
Standard Warrants
Entity Filer Category
Entity Filer Category
Total liabilities and stockholders' equity
Liabilities and Equity
Debt Instrument [Line Items]
Debt Instrument [Line Items]
Less: term loan, current portion
Long-Term Debt, Current Maturities
Term loan, current portion
Long-term Debt, Current Maturities, Total
Long-Lived Tangible Asset [Axis]
Two thousand and sixteen equity incentive plan.
Two Thousand And Sixteen Equity Incentive Plan [Member]
2016 Equity Incentive Plan
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Increase in net valuation allowance
Share-based compensation arrangement by share-based payment award, options, early exercised, shares.
Share Based Compensation Arrangement By Share Based Payment Award Options Early Exercised Shares
Number of shares early exercised under any plan
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
Deferred tax true ups
Effective Income Tax Rate Reconciliation Deferred Tax True Ups
Effective income tax rate reconciliation deferred tax true ups.
Cash and Cash Equivalents, Fair Value Disclosure
Cash and cash equivalents, fair value
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Valuation Allowance, Total
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
U.S. federal taxes at statutory rate
Subsequent Event [Line Items]
Subsequent Event [Line Items]
Organization and principal activities.
Organization And Principal Activities [Table]
Organization And Principal Activities [Table]
Cybersecurity Risk Management Third Party Engaged [Flag]
Documents Incorporated by Reference
Documents Incorporated by Reference [Text Block]
Effective Income Tax Rate Reconciliation, Percent
Effective tax rate
Common stock options, issued and outstanding
Income Tax Jurisdiction [Axis]
Income Tax Authority
Research and Development Arrangement, Contract to Perform for Others, Description and Terms
Research term
Geographical [Domain]
Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Fair value of pre-funded warrants issued
Fair Value of Pre Funded Warrants Issued
Fair value of pre-funded warrants issued.
Additional Paid in Capital, Common Stock
Additional paid-in capital
Additional Paid in Capital, Common Stock, Beginning Balance
Additional Paid in Capital, Common Stock, Ending Balance
Short Term Debt Commercial Paper Member
Short-Term Debt, Commercial Paper [Member]
Short-Term Debt, Commercial Paper Member.
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Property, Plant and Equipment [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Terms of Award
Equity incentive plans terms
Loan Agreement with Avenue Capital [Member]
Loan agreement with avenue capital.
Loan Agreement with Avenue Capital
Measurement Input, Risk Free Interest Rate [Member]
Risk-free interest rate
Vesting [Domain]
Vesting
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Granted, Outstanding Stock Options
Options granted to purchase shares of common stock
Cybersecurity Risk Management, Strategy, and Governance [Table]
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Schedule of Computation of Basic and Diluted Net Loss Per Share
Probable of Achievement
Probable Of Achievement [Member]
Probable of achievement member.
Percentage of Price Per Share Equal Exercise Price
Percentage of price per share equal exercise price.
Percentage of price per share equal exercise price
Recent accounting pronouncements not yet adopted.
Recent Accounting Pronouncements Not Yet Adopted Policy [Text Block]
Recent Accounting Pronouncements - Not Yet Adopted
Net loss per share, basic
Earnings Per Share, Basic
Earnings Per Share, Basic, Total
Repayments of Long-term Debt, Total
Repayments of Long-Term Debt
Repayment of term loan
Repayment of term loan
Series B redeemable convertible preferred stock.
Series B Redeemable Convertible Preferred Stock [Member]
Series B Redeemable Convertible Preferred Stock
Retirement Benefits [Text Block]
401(k) Retirement Savings Plan
Effective Income Tax Rate Reconciliation, Prior Year Income Taxes, Percent
Prior year true up
Number of options outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Ending Balance, Outstanding Stock Options
Beginning Balance, Outstanding Stock Options
Allievex Purchase Agreement
Allievex Purchase Agreement [Member]
Allievex purchase agreement.
Liabilities, Current
Total current liabilities
Income tax disclosure table.
Income Tax Disclosure [Table]
Income Tax Disclosure [Table]
Expiration Date of Pre-Funded Warrants
Expiration date of pre-funded warrants.
Pre-funded warrants, expiration period
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Non -Rule 10b51 Arrangement Modified [Flag]
Non -Rule 10b51 arrangement modified.
Non-Rule 10b5-1 Arrangement Modified
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Exercise Price
Reduced exercise price
Domestic Tax Jurisdiction [Member]
Federal
Unrecognized Tax Benefits, Increase Resulting from Prior Period Tax Positions
Increases based on tax positions related to prior period
Restructuring and Related Cost, Number of Positions Eliminated, Period Percent
Percentage of reduction in workforce
Equity, Attributable to Parent [Abstract]
Stockholders' equity:
Entity Small Business
Entity Small Business
Line of Credit Facility, Commitment Fee Amount
Commitment fee
Accrued expenses and other current liabilities
Increase (Decrease) in Accrued Liabilities
Increase (Decrease) in Accrued Liabilities, Total
Share based compensation arrangement by share based payment award maximum term.
Share Based Compensation Arrangement By Share Based Payment Award Maximum Term
Equity incentive plan, maximum term
Short-Term Debt [Member]
Short Term Investments
Research and Development [Abstract]
Retained Earnings (Accumulated Deficit)
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Retained Earnings (Accumulated Deficit), Beginning Balance
Retained Earnings (Accumulated Deficit), Ending Balance
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
Stock based compensation
Prior to the Second Anniversary [Member]
Prior to the second anniversary.
Prior to the second anniversary
Loss on disposal of property and equipment
Loss on disposal of property and equipment
Loss on Disposal of Property and Equipment
Development and Regulatory Milestones
Development and regulatory milestones
Development and regulatory milestones
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings
Restricted Stock, Value, Shares Issued Net of Tax Withholdings
Rule 10b5-1 Arrangement Modified [Flag]
Rule 10b5-1 Arrangement Modified.
Rule 10b5-1 Arrangement Modified.
Entity Well-known Seasoned Issuer
Entity Well-known Seasoned Issuer
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Forfeited, Outstanding Stock Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Aggregate intrinsic value of options exercised
Risks and uncertainties..
Risks And Uncertainties Policy [Text Block]
Risks and Uncertainties
Pre-funded warrants
Warrants and Rights Outstanding, Measurement Input
Stock-Based Compensation
Share-Based Payment Arrangement [Text Block]
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Leases [Abstract]
Lessee, Lease, Description [Line Items]
Amendment Flag
Amendment Flag
Product and Service [Domain]
Money Market Fund [Member]
Money Market Fund Member.
Money Market Fund
Loss Contingencies [Line Items]
U.S. federal taxes at statutory rate
Effective Income Tax Rate Reconciliation at Federal Statutory Income Tax Rate, Amount
Proceeds from maturities of investments
Proceeds from Sale, Maturity and Collection of Investments
Proceeds from Sale, Maturity and Collection of Investments, Total
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of warrants issued
Earnings Per Share, Policy [Policy Text Block]
Net Loss per Share
Liabilities and Equity [Abstract]
LIABILITIES AND STOCKHOLDERS' EQUITY
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation
Net cash used in operating activities
Common Stock [Member]
Common Stock
Cybersecurity Risk Role of Management [Text Block]
Tax Credit Carryforward, Amount
Tax credit carryforward, amount
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Granted, Weighted-Average Exercise Price
Options granted to purchase shares of common stock, weighted-average exercise price
Lessee, Operating Lease, Liability, to be Paid, Year Three
2028
Tax credit carryforward expiration year.
Tax Credit Carryforward Expiration Year
Tax credit carryforward expiration year
Incurred Operating Expense
Incurred operating expense.
Incurred operating expenses
Entity Address, Address Line One
Entity Address, Address Line One
Deferred Tax Liabilities, Gross
Total deferred tax liabilities
Total deferred tax liabilities
Total deferred tax liabilities
Fair Value Hierarchy and NAV [Axis]
Clinical Development Milestones
Clinical Development Milestones [Member]
Clinical development milestones member.
Earnings Per Share [Abstract]
Income Tax, Policy [Policy Text Block]
Income Taxes
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Fair value, total
Fair value, total
Debt Securities, Available-for-Sale, Unrealized Loss Position
Deferred Tax Assets, Gross
Total gross deferred tax assets
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Class of Warrant or Right [Axis]
Class of Warrant or Right
Document Type
Document Type
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Share based compensation arrangement by share based payment award options termination term if option holders service terminate.
Share Based Compensation Arrangement By Share Based Payment Award Options Termination Term If Option Holders Service Terminate
Options termination term, if option holders service terminate
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Entity Central Index Key
Entity Central Index Key
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Prime Rate [Member]
Prime Rate
Number of patent
Number of Patent
Number of patent.
Effective Income Tax Rate Reconciliation, Changes in Unrecognized Tax Benefits
Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in unrecognized tax benefits.
Changes in unrecognized tax benefits
Share-based compensation arrangement by share-based payment award, term of automatically increase in common stock available for issuance.
Share Based Compensation Arrangement By Share Based Payment Award Term Of Automatically Increase In Common Stock Available For Issuance
Term of automatically increase in common stock available for issuance
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Excluding Exchange Rate Effect, Including Discontinued Operation
Net increase (decrease) in cash, cash equivalents, and restricted cash
Subsequent Event Type [Domain]
Subsequent Event Type
Fair Value Adjustment of Warrants
Change in fair value of warrant liability
Change in fair value
Change in fair value of warrant liability
Restricted Stock Units Issued And Outstanding [Member]
Restricted Stock Units Issued And Outstanding Member
Restricted stock units, issued and outstanding
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
Potential dilutive securities excluded from diluted net loss per share
Balance Sheet Related Disclosures [Abstract]
Common Stock, Par or Stated Value Per Share
Common stock, par value
Common stock par value
Sales Milestones
Sales milestones
Sales milestones
First tranche term loan.
First Tranche Term Loan [Member]
First Tranche Term Loan
Share-Based Payment Arrangement, Tranche One [Member]
First Anniversary
Base Rate [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted-Average Remaining Contractual Life (Years)
Other liabilities
Increase (Decrease) in Other Operating Liabilities, Total
Increase (Decrease) in Other Operating Liabilities
Amortized Cost
Debt Securities, Available-for-Sale, Amortized Cost
Cash equivalents and available for sale securities, amortized cost
Debt Securities, Available-for-Sale
Available for sale securities debt securities
Available for sale, fair value
Debt and Equity Securities
Available for sale, fair value
Daly City, California
Daly City, California [Member]
Daly City, California.
Document Financial Statement Error Correction [Flag]
Document Financial Statement Error Correction [Flag]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Exercise of common stock options, Shares
Number of options exercised
Exercised, Outstanding Stock Options
Debt Disclosure [Abstract]
Supplemental Cash Flow Elements [Abstract]
Supplemental cash flow data:
Accrued Liabilities, Current
Total accrued expenses and other current liabilities
Termination Date
Termination date.
Termination date
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Current Fiscal Year End Date
Current Fiscal Year End Date
Schedule of Long-Term Debt Instruments [Table]
Debt Instrument [Table]
Entity Address, State or Province
Entity Address, State or Province
Deferred tax liabilities right-of-use assets.
Deferred Tax Liabilities Right-of-use Assets
Lease right-of-use asset
Financial Liabilities Fair Value Disclosure, Total
Financial Liabilities Fair Value Disclosure
Financial Liabilities Fair Value Disclosure, Total
Preferred Stock, Shares Outstanding
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding, Beginning Balance
Preferred Stock, Shares Outstanding, Ending Balance
Tranche One [Member]
Tranche one
Tranche 1
Research and Development Expense, Policy [Policy Text Block]
Research and Development Expenses
Common Stock, Capital Shares Reserved for Future Issuance
Shares reserved for future issuance
Gross proceeds
Proceeds from Collection of Loans Receivable
Class of Warrant or Right [Domain]
Class of Warrant or Right
Geographical [Axis]
Kaken License Agreement
Kaken License Agreement [Member]
Kaken License Agreement
Accrued general and administrative expenses.
Accrued General And Administrative Expenses
Accrued general and administrative expenses
Summary of Stock-Based Compensation Expense Related to Stock Options, RSUs and ESPP
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Amount
Other
Discretionary Tranche Four [Member]
Discretionary tranche four
Discretionary Tranche 4
Stock Issued During Period, Value, Stock Options Exercised
Exercise of common stock options
Preferred Stock, Redemption Price Per Share
Preferred stock redemption price per share
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Schedule of Significant Components of Net Deferred Tax Assets and Liabilities
Interest and other income, net
Interest and Other Income
Collaborative Arrangement Disclosure [Text Block]
License and Purchase Agreements
Subsequent Event [Member]
Subsequent Event
Fair market value exercise price percentage.
Fair Market Value Exercise Price Percentage
Fair market value exercise price percentage
Debt securities, available-for-sale, realized gain (loss), excluding other-than-temporary impairment
Debt Securities, Available-for-Sale, Realized Gain (Loss), Excluding Other-than-temporary Impairment
Deferred Revenue, Current, Total
Deferred Revenue, Current
Deferred revenue
Increase in shares available for grant
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Additional Shares Authorized
Other Assets, Noncurrent
Other assets
Other Assets, Noncurrent, Total
Fair Value Measurement Inputs and Valuation Techniques [Table]
Measurement Input, Expected Term [Member]
Expected term
Antidilutive Securities [Axis]
Antidilutive Securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Vesting percentage
Fair value of RSUs vested in period
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value
Vested and expected to vest, Aggregate Intrinsic Value
Second tranche term loan.
Second Tranche Term Loan [Member]
Second Tranche Term Loan
State and Local Jurisdiction [Member]
State
Lessee, Operating Lease, Option to Extend
Operating Leases, option to renew lease term description
Preferred Stock, Value, Issued
Preferred Stock, Value, Issued, Total
Preferred Stock, Value, Issued, Beginning Balance
Preferred Stock, Value, Issued, Ending Balance
Preferred stock, $0.0001 par value; 10,000,000 shares authorized and no shares issued or outstanding as of December 31, 2025 and 2024
Asset Acquisition, Consideration Transferred, Contingent Consideration
Contingent consideration paid
Expiration Date
Warrant expired date
Debt Instrument, Maturity Date
Minimum [Member]
Minimum
Weighted Average Grant Date Fair Value Per Share, Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted Average Grant Date Fair Value Per Share
Potential milestone payments payable.
Potential Additional Payment
Potential additional payment
Financial Instrument [Axis]
Effective Income Tax Rate Reconciliation Nondeductible Expense Related to Tax Credits Percent
Effective income tax rate reconciliation nondeductible expense related to tax credits percent
Nondeductible expenses related to tax credits
Assets, Current [Abstract]
Current assets:
Common stock and warrant net offering costs.
Common Stock and Warrant Net Offering Costs
Offering costs
Employer contribution plan expense incurred
Defined Contribution Plan, Administrative Expense
Incentive stock options granted description.
Incentive Stock Options Granted Description
Incentive stock options granted description
Vest Period of Stock-Based Compensation
Vest period of stock-based compensation.
Vest period
Fair Value, Inputs, Level 3 [Member]
Level 3
Fair Value, Nonrecurring [Member]
Fair Value Non-recurring
Deferred Tax Liabilities, Property, Plant and Equipment
Property and equipment
Property and equipment
Summary of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis
Fair Value, Assets Measured on Recurring Basis [Table Text Block]
Liabilities, Current [Abstract]
Current liabilities:
Shares subject to outstanding common stock options
Shares subject to outstanding common stock options.
Shares Subject To Outstanding Common Stock Options [Member]
Related Party Transactions [Abstract]
Summary of investments in an unrealized loss position
Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table Text Block]
Operating Loss Carryforwards
Net operating loss carryforwards
Operating Loss Carryforwards, Total
Lessee, Operating Lease, Renewal Term
Operating leases, renew lease term
Operating loss carryforwards expiration year.
Operating Loss Carryforwards Expiration Year
Net operating loss carryforwards expiration year
Total gross proceeds
Proceeds from Stock Plans
Proceeds from issuance of common stock related to employee stock purchase plan
Commitments and contingencies (Note 7)
Commitments and Contingencies
Lessee, Leases [Policy Text Block]
Leases
Series A Redeemable Preferred Stock
Series A Redeemable Preferred Stock [Member]
Series A redeemable preferred stock.
Upfront payments
Upfront Payments
Upfront payments
General and Administrative Expense [Member]
General and Administrative
Total operating lease liability
Operating Lease, Liability
Lease liability
Auditor Firm ID
Common stock warrants, issued and outstanding
Common Stock Warrants [Member]
Common Stock Warrants [Member]
Lessee, Lease, Description [Table]
Prior to the First Anniversary [Member]
Prior to the first anniversary.
Prior to the first anniversary
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Change in valuation allowance
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Loss Contingencies [Table]
Weighted Average Number of Shares Outstanding, Basic
Weighted-average shares of common stock outstanding, basic
Weighted Average Number of Shares Outstanding, Basic, Total
HBM Warrant Liability
H B M Warrant Liability [Member]
H B M warrant liability.
Orphan Drug Credits Carryforwards [Member]
Orphan Drug Credits Carryforwards.
Orphan Drug Credits Carryforwards
Shares available for future issuance under two thousand and twenty equity incentive plan.
Shares Available For Future Issuance Under Two Thousand And Twenty Equity Incentive Plan [Member]
Shares available for future issuance under 2020 Equity Incentive Plan
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Schedule of Reconciliation of the Federal Statutory Income Tax Rate to Effective Tax Rate
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Gross unrealized losses, twelve months or greater
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, 12 Months or Longer, Accumulated Loss
Long-Lived Tangible Asset [Domain]
Stock Issued During Period, Shares, Reverse Stock Splits
Reverse stock split , shares
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Proceeds from Issuance of Private Placement
Proceeds from issuance of private placement
Subsequent Events [Text Block]
Subsequent Events
Asset Acquisition, Consideration Transferred, Transaction Cost
Transaction costs
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Credits
Long term debt
Total
Long-Term Debt
Aggregate principal amount
Related Party Transactions Disclosure [Text Block]
Related Party Transactions
Exercise Payment
Exercise payment.
Exercise payment
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Variable Rate [Domain]
Variable Rate
Capitalized research costs
Deferred Tax Asset, In-Process Research and Development
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount
Change in valuation allowance
Equity, Attributable to Parent
Total stockholders' equity
Balance
Balance
Payments to Acquire Investments, Total
Payments to Acquire Investments
Purchases of investments
Purchases of investments
Preferred Stock, Par Value
Preferred Stock, Par or Stated Value Per Share
Basis of Accounting, Policy [Policy Text Block]
Basis of Presentation
Statement of Stockholders' Equity [Abstract]
Share-Based Payment Arrangement, Tranche Two [Member]
Monthly Anniversary
Use of Estimates, Policy [Policy Text Block]
Use of Estimates
Defined Benefit Plan Disclosure [Line Items]
Defined Benefit Plan Disclosure [Line Items]
Over-Allotment Option [Member]
Overallotment Option
Entity Address, Address Line Two
Entity Address, Address Line Two
Fair Value Disclosures [Text Block]
Fair Value Measurements
Operating lease termination date
Operating Lease Termination Month And Year
Operatingleaseterminationmonthandyear
Debt Instrument, Name [Domain]
Debt Instrument, Name
Other current assets
Other Assets, Current
Deferred tax true ups
Income Tax Reconciliation Deferred Tax True Ups
Income tax reconciliation deferred tax true ups.
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]
Schedule of Reconciliation of Beginning and Ending Balance of Unrecognized Tax Benefits
Plan Name [Domain]
Plan Name
Schedule of Weighted-Average Assumptions to Estimate Fair Value of Stock Options and Purchase Rights Under ESPP Using the Black-Scholes Option-Pricing Model
Schedule of Share-Based Payment Award, Employee Stock Purchase Plan, Valuation Assumptions [Table Text Block]
Increase (Decrease) in Other Operating Assets
Other assets
Increase (Decrease) in Other Operating Assets, Total
Interest Expense, Operating and Nonoperating
Interest expense
Interest Expense, Total
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Entity
Entity [Domain]
BioMarin [Member]
BioMarin [Member]
BioMarin [Member]
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Exercise Price
Vested and exercisable, Weighted-Average Exercise Price
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Effective Income Tax Rate Reconciliation Loss on Fair Value of Warrant Liability
Effective income tax rate reconciliation loss on fair value of warrant liability.
Loss on fair value of warrant liability
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings, Shares
Restricted Stock, Shares Issued Net of Shares for Tax Withholdings
Deferred offering costs included in accrued expenses.
Deferred Offering Costs Included In Accrued Expenses
Deferred offering costs included in accrued expenses
Property, Plant and Equipment, Policy [Policy Text Block]
Property and Equipment, Net
Entity Address, City or Town
Entity Address, City or Town
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Line Items]
Summary Of Significant Accounting Policies [Line Items]
Number of reportable segment
Number of Reportable Segments
Emerging growth company policy.
Emerging Growth Company Policy Policy [Text Block]
Emerging Growth Company Status
Security Exchange Name
Security Exchange Name
Value of common stock
Class of Warrant or Right, Number of Securities Called by Warrants or Rights Value
Class of warrant or right, number of securities called by warrants or rights value.
Counterparty Name [Axis]
Counterparty Name
Total stock options outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number
Vested and expected to vest, Outstanding Stock Options
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Granted
Shares, Granted
RSUs granted
Obligations to pay third party
Obligations to Pay Third Party
Obligations to pay third party.
Measurement Input Type [Domain]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Fair value as of December 31, 2024
Fair value as of December 31, 2025
Warrant Liability
Warrant liability.
Fair value as of December 31, 2024
Share-Based Payment Arrangement, Employee [Member]
Stock Option Granted to Executive Officers
Lease liability
Deferred Tax Assets Lease Liability
Deferred tax assets lease liability.
Deferred Tax Assets, Goodwill and Intangible Assets
Intangible assets
Total cash, cash equivalents, and restricted cash
Cash, cash equivalents, and restricted cash at end of period
Cash, cash equivalents, and restricted cash at beginning of period
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation
Share-Based Payment Arrangement, Nonemployee [Member]
Stock Options Granted to Nonemployees
Interest Paid, Excluding Capitalized Interest, Operating Activity
Cash paid for interest on term loan
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Statistical Measurement [Domain]
Statistical Measurement
Assets, Current
Total current assets
Lease liabilities, current portion
Present value of lessee's discounted obligation for lease payments from leases, classified as current.
Lease Liability Current
Share-Based Payment Arrangement, Expense
Total stock-based compensation expense
Compensation expense
Document Period End Date
Document Period End Date
Fair Value Hierarchy and NAV [Domain]
Two thousand and twenty employee stock purchase plan.
Two Thousand And Twenty Employee Stock Purchase Plan [Member]
2020 Employee Stock Purchase Plan
ICFR Auditor Attestation Flag
ICFR Auditor Attestation Flag
Accrued research and development expenses.
Accrued Research And Development Expenses
Accrued research and development expenses
Two thousand and twenty equity incentive plan.
Two Thousand And Twenty Equity Incentive Plan [Member]
2020 Equity Incentive Plan
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]
Lease liabilities, net of current portion
Summary of significant accounting policies.
Summary Of Significant Accounting Policies [Table]
Summary Of Significant Accounting Policies [Table]
Statement of Financial Position [Abstract]
Restricted Stock Units (RSUs) [Member]
RSU
RSU
Revenue [Policy Text Block]
Revenue Recognition
Class of Warrant or Right, Price of Pre Funded Warrants
Class of warrant or right, price of pre-funded warrants.
Purchase price for pre-funded warrants
Short Term Debt Corporate Bond Securities Member
Short-Term Debt , Corporate Bond Securities [Member]
Short-Term Debt , Corporate Bond Securities Member.
Long Term Debt Us Treasury Securities Member
Long-Term Debt, US Treasury Securities [Member]
Long-Term Debt, US Treasury Securities Member.
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Vesting [Axis]
Vesting
Reconciliation of cash, cash equivalents, and restricted cash
Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation [Abstract]
Class of Stock [Axis]
Class of Stock
Debt Instrument, Unused Borrowing Capacity, Amount
Additional term loans
Debt Securities, Available-for-sale, Realized Gain (Loss), Total
Debt Securities, Available-for-Sale, Realized Gain (Loss)
Debt securities, available-for-sale, realized gain (loss)
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Liabilities
Total liabilities
Financial Instruments [Domain]
Measurement Input, Exercise Price [Member]
Exercise price
Operating lease commencement date.
Operating Lease Commencement Month And Year
Operating lease commencement date
Deferred revenue
Increase (Decrease) in Deferred Revenue
South San Francisco, California
South San Francisco, California [Member]
South San Francisco, California.
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals
Deferred Tax Assets, Tax Deferred Expense, Reserves and Accruals, Total
Accruals and reserves
Lessee, Operating Lease, Liability, to be Paid, Year Two
2027
Restricted Cash
Restricted cash
Restricted Cash, Total
Series A redeemable convertible preferred stock.
Series A Redeemable Convertible Preferred Stock [Member]
Series A Redeemable Convertible Preferred Stock
Series A Redeemable Convertible Preferred Stock
Variable Rate [Axis]
Variable Rate
Shares subject to outstanding RSUs
Shares subject to outstanding restricted stock units.
Shares Subject to Outstanding Restricted Stock Units [Member]
Gross unrealized losses, less than twelve months
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months, Accumulated Loss
Weighted-average shares of common stock outstanding, diluted
Weighted Average Number of Shares Outstanding, Diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Entity File Number
Entity File Number
Number of shares Issued for common stock and warrants.
Stock Issued During Period Shares Of Common Stock And Warrants
Issuance of common stock, net of offering costs, shares
Cover [Abstract]
Cover
General Business Tax Credit Carryforward
General Business Tax Credit Carryforward [Member]
Measurement Input Type [Axis]
Consideration assumed as accrued expenses and other current liabilities
Business Combination, Recognized Liability Assumed, Other Liability, Current
Supplemental Balance Sheet Disclosures [Text Block]
Balance Sheet Components
Deferred Tax Assets Tax Credit Write Off
Amount of deferred tax assets tax credit written off.
Deferred tax assets, tax credit written off
Long-Term Debt, Maturities, Repayment Terms
Long term debt, maturities, repayment terms
Number of Operating Segments
Number of operating segment
Sale of Stock [Domain]
Sale of Stock
letter of credit issued
Letter of Credit Issued
Letter of credit issued.
Research And Development Arrangement Contract To Perform For Others Expiration Date
Research And Development Arrangement Contract To Perform For Others Expiration Date
Research term, expiration date
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
Income Tax Disclosure [Line Items]
Income tax disclosure line items.
Income Tax Disclosure [Line Items]
Regulatory milestone.
Regulatory milestone
Regulatory Milestone
Shares, Vested
Shares, Vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested, Number of Shares
Subsequent Event [Table]
Subsequent Event [Table]
Schedule of property and equipment useful lives.
Schedule of Property and Equipment Useful Lives [Table Text Block]
Schedule of Useful Lives of Property and Equipment
Deferred Tax Assets, Other
Other
Expected lease term
Lessor, Operating Lease, Renewal Term
Grant Date Fair Value
Grant date fair value.
Grant date fair value
Weighted Average Grant Date Fair Value Per Share, Ending Balance
Weighted Average Grant Date Fair Value Per Share, Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Option, Nonvested, Weighted Average Exercise Price
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price
Vested and expected to vest, Weighted-Average Exercise Price
Property, Plant and Equipment, Useful Life
Property and equipment, useful Lives
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Accounting Pronouncements Adopted
Future Minimum Annual Lease Commitments Under Non-cancelable Operating Leases
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]
Summary of RSU Activity
Other
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Other, Percent
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Vesting period
Payment of Financing and Stock Issuance Costs
Payment of Financing and Stock Issuance Costs, Total
Payment of debt and equity offering costs
Term loan.
Term Loan [Member]
Term Loan
Research and Development Arrangement, Contract to Perform for Others, Costs Incurred, Gross
Research and development arrangement, costs incurred
U.S. government treasury securities
Us government treasury security.
Us Government Treasury Security [Member]
Common Stock, Shares, Outstanding
Balance, Shares
Balance, Shares
Common stock, shares outstanding
Operating Lease, Liability, Current, Total
Operating lease liability, current portion
Operating Lease, Liability, Current
Lease liabilities, current portion
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Cybersecurity Risk Management Processes Integrated [Flag]
Document Transition Report
Document Transition Report
Operating Expenses
Total operating expenses
Research and Development Expense
Research and development expense
Research and development
Research and Development Expense, Total
Impairment losses
Asset Impairment Charges
Asset Impairment Charges, Total
Effective Income Tax Rate Reconciliation, Nontaxable and Nondeductible Items, Section 383 Limitation - Credits
Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to Section 383 Limitation Credits.
Section 383 limitation - credits
Lessee, Operating Leases [Text Block]
Leases
Long Term Debt Corporate Bond Securities Member
Long-Term Debt, Corporate Bond Securities [Member]
Long-Term Debt, Corporate Bond Securities Member
Statement of Cash Flows [Abstract]
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Stock Option Activity
Payments to Acquire Businesses, Net of Cash Acquired
Payments to Acquire Businesses, Net of Cash Acquired, Total
Aggregate net acquisition cost
Equity [Text Block]
Capital Structure
Earnings Per Share [Text Block]
Net Loss Per Share
Schedule of Accrued Expenses and Other Current Liabilities
Schedule of accrued expenses and other current liabilities.
Schedule of Accrued Expenses and Other Current Liabilities [Table Text Block]
Measurement Input, Expected Dividend Rate [Member]
Expected dividend rate
Deferred Tax Liabilities, Other
Other
Other
Cybersecurity Risk Management Processes Integrated [Text Block]
Net loss
Net loss and comprehensive loss
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value
Cash And Cash Equivalent Member
Cash and Cash Equivalent [Member]
Cash and Cash Equivalent Member.
Operating lease costs
Operating Lease, Cost
Warrants and Rights Outstanding, Term
Pre-funded warrants, Term
Cash Provided by (Used in) Operating Activity, Continuing Operation
Cash in operations
Net Cash Provided by (Used in) Operating Activities, Continuing Operations, Total
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend rate
Cash paid for operating lease liabilities
Operating Lease, Payments
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Aggregate Intrinsic Value
Vested and exercisable, Aggregate Intrinsic Value
Adjustments to Additional Paid in Capital Warrant Exercised
Amount of increase to additional paid in capital (APIC) resulting from the exercising of warrants.
Reclass to additional paid-in capital upon exercise
Assets [Abstract]
ASSETS
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Prepaid expenses and other current assets
Increase (Decrease) in Prepaid Expense and Other Assets
Document Fiscal Year Focus
Document Fiscal Year Focus
Deferred offering costs included in accrued expenses and other current liabilities
Deferred Offering Costs Included In Accrued Expenses And Other Current Liabilities
Deferred offering costs included in accrued expenses and other current liabilities.
Lilly License Agreement
Lilly License Agreement [Member]
Lilly license agreement member.
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation [Abstract]
Cash flows from investing activities
Retirement Benefits [Abstract]
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Options vested in period, fair value
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested in Period, Fair Value
Area of office space
Land Subject to Ground Leases
Research and Development Expense [Member]
Research and Development
Research and Development Tax Credit Carry Forwards
Research Tax Credit Carryforward [Member]
Outstanding principal of the loans
Debt Conversion, Converted Instrument, Amount
Fair Value Measurement, Policy [Policy Text Block]
Fair Value of Financial Instruments
Income Tax Reconciliation Nondeductible Expense Related to Tax Credits
Income tax reconciliation nondeductible expense related to tax credits.
Nondeductible expenses related to tax credits
Debt Securities, Available-for-Sale, Unrealized Loss Position [Line Items]
Proceeds from Stock Options Exercised
Proceeds from exercise of common stock options
Fair Value Disclosures [Abstract]
Commitments and Contingencies Disclosure [Abstract]
Tax credits, net of reserve
Effective Income Tax Rate Reconciliation, Tax Credit, Amount
Effective Income Tax Rate Reconciliation, Tax Credit, Amount, Total
Credits
Lessee, Operating Lease, Liability, to be Paid, Year One
2026
Pre-Funded Warrants
Pre-Funded Warrants [Member]
Pre-Funded Warrants [Member]
Debt Securities, Available-for-Sale, Unrealized Loss Position, Fair Value [Table]
Debt Instrument [Axis]
Debt Instrument
Tranche Three [Member]
Tranche Three
Tranche 3
Effective Income Tax Rate Reconciliation, Nontaxable and Nondeductible Items, Section 383 Limitation - Credits, Percentage
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to Section 383 limitation - credits.
Section 383 limitation - credits
Share-Based Payment Arrangement [Abstract]
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount
Unrecognized stock-based compensation expense
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount, Total
Assets, Fair Value Disclosure
Assets, Fair Value Disclosure, Total
Assets, Fair Value Disclosure, Total
Sale of Stock [Axis]
Sale of Stock
Research And Development Arrangement Contract To Perform For Others Extension Payment
Research and development arrangement contract to perform for others extension payment
Extension payment
Debt Instrument, Fair Value Disclosure
Estimated fair value of term loan
Debt Instrument, Fair Value Disclosure, Total
Revenues, Total
Revenues
Collaboration revenue
Cash Provided by (Used in) Investing Activity, Including Discontinued Operation
Net cash provided by investing activities
Private Placement [Member]
Private Placement
Title of 12(b) Security
Title of 12(b) Security
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Forfeited, Weighted-Average Exercise Price
Weighted Average Grant Date Fair Value Per Share, Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
HMNC Holding GmbH [Member]
HMNC Holding GmbH [Member]
HMNC Holding GmbH [Member]
Research and Development Asset Acquired in Transaction Other than Business Combination or Joint Venture Formation, Writeoff, Statement of Income or Comprehensive Income [Extensible Enumeration]
Income Tax Disclosure [Text Block]
Income Taxes
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Total
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Beginning Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss, Ending Balance
Debt Securities, Available-for-Sale, Allowance for Credit Loss
Allowance for credit losses
Collaborative Arrangement and Arrangement Other than Collaborative [Table]
Schedule Of Collaborative Arrangements And Noncollaborative Arrangement Transactions [Table]
Other Liabilities, Noncurrent
Other liabilities
Other Liabilities, Noncurrent, Total
Legal Entity
Legal Entity [Axis]
Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Ending Balance, Weighted-Average Exercise Price
Beginning Balance, Weighted-Average Exercise Price
Number of pre-funded warrants exercised.
Exercise of Pre-funded Warrants, Shares
Exercise of pre-funded warrants, Shares
Income Tax Disclosure [Abstract]
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Financing transactions aggregate amount
Financing Transactions Aggregate Amount
Financing transactions aggregate amount.
HBM Alpha Therapeutics, Inc. [Member]
HBM Alpha Therapeutics, Inc. [Member]
HBM Alpha Therapeutics, Inc.
Unrecognized Tax Benefits
Balance at the end of the year
Balance at the beginning of the year
Unrecognized tax benefits
Additional Paid-in Capital [Member]
Additional Paid-In Capital
SVB Term Loan [Member]
SVB term loan.
SVB Term Loan
Measurement Frequency [Domain]
Measurement Frequency
Statement of Income Location, Balance [Axis]
Income Statement Location
Trading Symbol
Trading Symbol
Related Party Transaction [Table]
After the First Anniversary [Member]
After the first anniversary.
After the first anniversary
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Nondeductible items
Subsequent Event Type [Axis]
Subsequent Event Type
Twist License Agreement [Member]
Twist License Agreement [Member]
Twist License Agreement
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation [Abstract]
Cash flows from financing activities
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (in years)
Fair Value, Recurring [Member]
Fair Value Recurring
Entity Ex Transition Period
Entity Ex Transition Period
Estimated shares issuable under the ESPP
Estimated shares issuable under the employee stock purchase plan.
Estimated Shares Issuable Under Employee Stock Purchase Plan [Member]
Lessee, Operating Lease, Liability, to be Paid
Total undiscounted operating lease payments
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: present value discount
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Share-Based Compensation Arrangement by Share-Based Payment Award, Maximum Employee Subscription Rate
Maximum percentage of compensation that an employee is allowed to purchase shares
Equity Components [Axis]
Equity Components
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Weighted Average Remaining Contractual Term
Vested and exercisable, Weighted-Average Remaining Contractual Life (Years)
Equity Component [Domain]
Equity Component
Incurred Operating Expenses
Incurred operating expenses.
Incurred operating expenses
Document Annual Report
Document Annual Report
IPO [Member]
Initial Public Offering
Machinery and Equipment [Member]
Manufacturing Machinery and Equipment
Issuance of common stock related to employee stock purchase plan, Shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
ESPP issued
Depreciation and amortization
Depreciation, Depletion and Amortization, Nonproduction
Depreciation, Depletion and Amortization, Nonproduction, Total
Common Stock, Voting Rights
Common stockholders voting rights
Maximum [Member]
Maximum
Maximum [Member]
Liabilities, Fair Value Disclosure, Total
Liabilities, Fair Value Disclosure
Liabilities fair value
Percentage of incentive stock options granted.
Percentage Of Incentive Stock Options Granted
Percentage of incentive stock options granted
Statistical Measurement [Axis]
Statistical Measurement
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Exercised, Weighted-Average Exercise Price
Prepaid expenses
Prepaid Expense, Current
Prepaid Expense, Current, Total
Summary of Common Stock Reserved for Future Issuance
Common Stock Capital Shares Reserved For Future Issuance Table [Text Block]
Common stock capital shares reserved for future issuance.
Common Stock, Value, Issued
Common Stock, Value, Issued, Total
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Ending Balance
Common stock, $0.0001 par value; 200,000,000 shares authorized as of December 31, 2025 and 2024; 1,372,043 and 563,042 shares issued and outstanding as of December 31, 2025 and 2024, respectively
Share Based Compensation Award Tranche Four [Member]
Share Based Compensation Award Tranche Four [Member]
Performance Based Vesting
Proceeds from Issuance of Common Stock and Warrants
The cash inflow from the issuance of common stock and warrants.
Proceeds from issuance of common stock and warrants
Percentage of Shares Vest
Percentage of shares vest.
Percentage of shares vest
Deferred Tax Assets, Operating Loss Carryforwards
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Tax Credit Carryforward
Tax Credit Carryforward [Axis]
Computer and office equipment.
Computer And Office Equipment [Member]
Computer and Office Equipment
Entity Public Float
Entity Public Float
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility
Preferred Stock, Shares Authorized
Preferred stock, shares authorized
Exercise of pre-funded warrants
Value of pre-funded warrants exercised.
Exercise of Pre-funded Warrants
Tax withholding payments on restricted stock units
Payment, Tax Withholding, Share-Based Payment Arrangement
Gross unrealized losses, total
Gross unrealized losses, total
Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss
Debt Securities, Available-for-Sale, Unrealized Loss Position, Accumulated Loss, Total
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Related Party Transaction [Line Items]
Employee Stock [Member]
Shares available for future issuance under 2020 Employee Stock Purchase Plan
Entity Registrant Name
Entity Registrant Name
SVB Term Loan
Debt Disclosure [Text Block]
Entity Voluntary Filers
Entity Voluntary Filers
After the second anniversary
After the Second Anniversary [Member]
After the second anniversary.
Payments to Acquire in Process Research and Development
Payments to acquire in process research and development
MPSIIIB [Member]
MPSIIIB [Member]
MPSIIIB [Member]
Subsequent Events [Abstract]
Lender success fee
Lender Success Fee
Lender success fee.
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Income Tax Expense (Benefit)
Income tax expense
Effective tax rate
Measurement Frequency
Measurement Frequency [Axis]
Shares subject to repurchase upon early exercise of options
Share-Based Compensation Arrangement by Share-Based Payment Award, Shares to be Repurchased Next Year
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Schedule of Pre-funded Warrants Measured Using Black-Scholes Option Pricing Model
Fair Value Measurement Inputs and Valuation Techniques [Table Text Block]
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Concentration of Credit Risk
Payments to Acquire Property, Plant, and Equipment
Purchases of property and equipment
Payments to Acquire Property, Plant, and Equipment, Total
Assets
Total assets
Property, Plant and Equipment [Table]
Income Statement [Abstract]
Retirement Plan Name [Domain]
Retirement Plan Name
Collateralized by a restricted cash deposit
Unrecognized Cash Deposit Collateral
Unrecognized cash deposit collateral.
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions
Decreases based on tax positions related to prior period
Intrinsic value of RSUs outstanding
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Aggregate Intrinsic Value, Outstanding
Share-Based Payment Arrangement [Policy Text Block]
Stock-Based Compensation
Legal costs
Legal Fees
General and administrative expenses [Member]
Selling, General and Administrative Expenses [Member]
Silicon valley bank.
Silicon Valley Bank [Member]
Silicon Valley Bank
Stock Issued During Period, Shares, New Issues
Initial public offering of common stock, net of underwriting expenses and offering costs of $10,149, Shares
Initial public offering of common stock
Net loss per share, diluted
Earnings Per Share, Diluted
Earnings Per Share, Diluted, Total
Comprehensive Loss
Comprehensive Loss PolicyTextBlock
Comprehensive loss
Dividends, Common Stock
Common stock dividends declared
Dividends, Common Stock, Total
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
Property, Plant, and Equipment, Useful Life, Term, Description [Extensible Enumeration]
City Area Code
City Area Code
Business Combination, Consideration Transferred, Liabilities Incurred
Consideration assumed as certain liabilities
Amount of lessee's right to use underlying asset under leases.
Lease Right of Use Asset
Right-of-use assets
Auditor Name
Effective Income Tax Rate Reconciliation, Changes in Unrecognized Tax Benefits, Percentage
Percentage of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to changes in unrecognized tax benefits.
Changes in unrecognized tax benefits
Income Tax Examination, Penalties and Interest Expense
Income tax penalties or interest
Income Tax Examination, Penalties and Interest Expense, Total
Aggregate principal amount
Debt Instrument, Face Amount
Defined Benefit Plan [Table]
Schedule Of Defined Benefit Plans Disclosures [Table]
Deferred Tax Assets, Tax Credit Carryforwards
Tax credits
Deferred Tax Assets, Tax Credit Carryforwards, Total
Counterparty Name [Domain]
Counterparty Name
Percentage of Issued Pre-Funded Warrants
Percentage of issued pre-funded warrants.
Percentage of issued pre-funded warrants
Stock Issued During Period, Value, Employee Stock Purchase Plan
Issuance of common stock related to employee stock purchase plan
Organization and principal activities.
Organization And Principal Activities [Line Items]
Organization And Principal Activities [Line Items]
Weighted average remaining lease term (years)
Operating Lease, Weighted Average Remaining Lease Term
Retirement Plan Name [Axis]
Retirement Plan Name
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash and Cash Equivalents
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Exercisable, Number
Vested and exercisable, Outstanding Stock Options
Loss from operations
Operating Income (Loss)
Loss from operations
Loss from operations
Retained Earnings [Member]
Accumulated Deficit
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense, Total
Measurement Input, Price Volatility [Member]
Expected stock price volatility
Stock-based compensation expense
Compensation Expense, Excluding Cost of Good and Service Sold
Payments of Stock Issuance Costs
Payment of offering costs
Fair value, less than twelve months
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Weighted average discount rate
Operating Lease, Weighted Average Discount Rate, Percent
Operating lease liability, net of current portion
Operating Lease, Liability, Noncurrent
Lease liabilities, net of current portion
Fair Value, Inputs, Level 1 [Member]
Level 1
Class of Stock [Line Items]
Class Of Stock [Line Items]
Net cash provided by (used in) financing activities
Cash Provided by (Used in) Financing Activity, Including Discontinued Operation
HMNC Agreement
HMNC Agreement [Member]
HMNC agreement.
Other Information Related to Operating Leases
Lease, Cost [Table Text Block]
Auditor Location
Long-Term Debt [Member]
Long Term Investments
Investments
Investments, Fair Value Disclosure, Total
Investments, Fair Value Disclosure
Schedule of Aggregate Fair Value of Warrant Liability
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]
Business Combination, Recognized Asset Acquired, Receivable, Current
Estimated receivable
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Per Share
Corporate bonds
Corporate Debt Securities [Member]
Income Tax Jurisdiction [Domain]
Income Tax Authority
Entity Interactive Data Current
Entity Interactive Data Current
Deferred Tax Liabilities, Gross [Abstract]
Deferred tax liabilities:
Statement of Income Location, Balance [Domain]
Income Statement Location
Employee stock purchase plan offering period.
Employee Stock Purchase Plan Offering Period
Employee stock purchase plan offering period
Cash Provided by (Used in) Operating Activity, Including Discontinued Operation [Abstract]
Cash flows from operating activities
Furniture and Fixtures [Member]
Furniture and Fixtures
Loss Contingency, Accrual, Current
Loss contingency, accrual, current
Accretion (Amortization) of Discounts and Premiums, Investments
Net accretion of discount on available-for-sale securities
All Other Options
All other options.
All Other Options [Member]
Entity Tax Identification Number
Entity Tax Identification Number
Share Price
Preferred Stock, Share price
Share price
Debt Instrument, Term
Debt instrument, term
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]
Organization and Principal Activities
401(K) Plan
Four zero one k plan.
Four Zero One K Plan [Member]
Local Phone Number
Local Phone Number
Auditor Opinion [Text Block]
Share-Based Compensation Arrangement by Share-Based Payment Award, Non-Option Equity Instruments, Forfeitures
Shares, Forfeited
Accounting Policies [Abstract]
Percentage of exercise price of incentive stock options granted owns stock.
Percentage Of Exercise Price Of Incentive Stock Options Granted Owns Stock
Percentage of Exercise price of incentive stock options granted owns stock
Net Income (Loss) Attributable to Parent [Abstract]
Numerator:
Potential additional cash receipt.
Potential Additional Cash Receipt
Potential additional cash receipt
Class of Stock [Domain]
Class of Stock
Total minimum rental payments
Operating Leases, Future Minimum Payments Due
Debt Conversion, Description
Debt conversion description
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Shares remained available for issuance
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized stock-based compensation expense expected to be recognized over weighted-average vesting term
Cash, cash equivalents, and short-term investments
Cash, Cash Equivalents, and Short-Term Investments
Cash, Cash Equivalents, and Short-Term Investments, Total
Stock, Class of Stock [Table]
Schedule Of Stock By Class [Table]
Entity Emerging Growth Company
Entity Emerging Growth Company
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term
Vested and expected to vest, Weighted-Average Remaining Contractual Life (Years)
Tax Credit Carryforward, Name [Domain]
Tax Credit Carryforward, Name