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<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2021-03-22T15:29:51.3827512+00:00 -->
<!-- Version            : 5.0.1.571 -->
<!-- Package ID         : b62b585999444c83a756287bed99c183 -->
<!-- Copyright (c) 2021 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="sprb_EndOfTermPaymentPercentage" name="EndOfTermPaymentPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_EndOfTermPaymentAmount" name="EndOfTermPaymentAmount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="sprb_DebtInstrumentPrepaymentFeePercentage" name="DebtInstrumentPrepaymentFeePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_NumberOfSharesIssuableUponExerciseOfWarrants" name="NumberOfSharesIssuableUponExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_EstimatedFairValueOfWarrant" name="EstimatedFairValueOfWarrant" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="sprb_DebtInstrumentUnamortizedDebtIssuanceCostsAndDiscount" name="DebtInstrumentUnamortizedDebtIssuanceCostsAndDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="sprb_StockOptionsAvailableForFutureIssuanceMember" name="StockOptionsAvailableForFutureIssuanceMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_TemporaryEquityIssuePricePerShare" name="TemporaryEquityIssuePricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="sprb_RedeemableConvertiblePreferredStockholdersEntitledToReceiveGreaterOfMaximumParticipationPricePerShare" name="RedeemableConvertiblePreferredStockholdersEntitledToReceiveGreaterOfMaximumParticipationPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="sprb_PotentialMinimumGrossCashProceedsFromRedeemableConvertiblePreferredStock" name="PotentialMinimumGrossCashProceedsFromRedeemableConvertiblePreferredStock" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="sprb_PotentialMinimumPublicOfferingPricePerShare" name="PotentialMinimumPublicOfferingPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_TemporaryEquityConversionBasis" name="TemporaryEquityConversionBasis" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_TemporaryEquityConversionPricePerShare" name="TemporaryEquityConversionPricePerShare" type="num:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="sprb_RedeemableConvertiblePreferredStockHoldersVotingRights" name="RedeemableConvertiblePreferredStockHoldersVotingRights" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_NumberOfDirectorsEntitledToBeElected" name="NumberOfDirectorsEntitledToBeElected" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_RedeemablePreferredStockDividendsDeclaredPercentage" name="RedeemablePreferredStockDividendsDeclaredPercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_RedeemablePreferredStockDividendsDeclared" name="RedeemablePreferredStockDividendsDeclared" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="sprb_ShareBasedCompensationArrangementByShareBasedPaymentAwardTermOfAutomaticallyIncreaseInCommonStockAvailableForIssuance" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardTermOfAutomaticallyIncreaseInCommonStockAvailableForIssuance" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_PercentageOfOutstandingSharesSubjectToAutomaticIncreaseInCommonStock" name="PercentageOfOutstandingSharesSubjectToAutomaticIncreaseInCommonStock" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_TwoThousandAndTwentyEquityIncentivePlanMember" name="TwoThousandAndTwentyEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_AllOtherOptionsMember" name="AllOtherOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_PerformanceStockOptionsMember" name="PerformanceStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_TwoThousandAndSixteenEquityIncentivePlanMember" name="TwoThousandAndSixteenEquityIncentivePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_PercentageOfIncentiveStockOptionsGranted" name="PercentageOfIncentiveStockOptionsGranted" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_PercentageOfExercisePriceOfIncentiveStockOptionsGrantedOwnsStock" name="PercentageOfExercisePriceOfIncentiveStockOptionsGrantedOwnsStock" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_FairMarketValueExercisePricePercentage" name="FairMarketValueExercisePricePercentage" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_IncentiveStockOptionsGrantedDescription" name="IncentiveStockOptionsGrantedDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumTerm" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardMaximumTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsTerminationTermIfOptionHoldersServiceTerminate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsTerminationTermIfOptionHoldersServiceTerminate" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsEarlyExercisedShares" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsEarlyExercisedShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="sprb_EmployeeStockPurchasePlanOfferingPeriod" name="EmployeeStockPurchasePlanOfferingPeriod" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_ClinicalAndSalesMilestonesPayments" name="ClinicalAndSalesMilestonesPayments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="sprb_LicenseAgreementMember" name="LicenseAgreementMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_EliLillyAndCompanyMember" name="EliLillyAndCompanyMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_IncomeTaxDisclosureLineItems" name="IncomeTaxDisclosureLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_IncomeTaxDisclosureTable" name="IncomeTaxDisclosureTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_TaxYear2021Member" name="TaxYear2021Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_TaxYear2022Member" name="TaxYear2022Member" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_OperatingLossCarryforwardsExpirationYear" name="OperatingLossCarryforwardsExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_TaxCreditCarryforwardExpirationYear" name="TaxCreditCarryforwardExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_GrossFederalTaxCreditRelatedDeferredTaxAssetsDerecognized" name="GrossFederalTaxCreditRelatedDeferredTaxAssetsDerecognized" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="sprb_SuspensionOfOperatingLossCarryforwardsOnTaxableIncome" name="SuspensionOfOperatingLossCarryforwardsOnTaxableIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="sprb_ThresholdPercentageOfTaxPositionsLikelyOfBeingRealizedUponUltimateSettlement" name="ThresholdPercentageOfTaxPositionsLikelyOfBeingRealizedUponUltimateSettlement" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_FourZeroOneKPlanMember" name="FourZeroOneKPlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_SharesSubjectToOutstandingCommonStockOptionsMember" name="SharesSubjectToOutstandingCommonStockOptionsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_EstimatedSharesIssuableUnderEmployeeStockPurchasePlanMember" name="EstimatedSharesIssuableUnderEmployeeStockPurchasePlanMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_SharesSubjectToCommonStockWarrantsMember" name="SharesSubjectToCommonStockWarrantsMember" type="nonnum:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="sprb_DebtInstrumentBasisSpreadVariableRateScenarioOne" name="DebtInstrumentBasisSpreadVariableRateScenarioOne" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_DebtInstrumentFrequencyOfPeriodicPaymentScenarioOne" name="DebtInstrumentFrequencyOfPeriodicPaymentScenarioOne" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_DebtInstrumentBasisSpreadVariableRateScenarioTwo" name="DebtInstrumentBasisSpreadVariableRateScenarioTwo" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="sprb_DebtInstrumentFrequencyOfPeriodicPaymentScenarioTwo" name="DebtInstrumentFrequencyOfPeriodicPaymentScenarioTwo" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
</xsd:schema>
