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SVB Term Loan - Additional Information (Details) - USD ($) $ in Thousands		12 Months Ended
	Nov. 03, 2025	Dec. 31, 2025	Dec. 31, 2024	Sep. 30, 2019
Debt Instrument [Line Items]
Repayment of term loan		$ 2,057	$ 1,622
SVB Term Loan
Debt Instrument [Line Items]
Repayment of term loan	$ 700
SVB Term Loan \| Silicon Valley Bank
Debt Instrument [Line Items]
Aggregate principal amount				$ 5,000

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Dec. 31, 2025
Trading Arrangements, by Individual
Rule 10b5-1 Arrangement Adopted	false
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
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Pay vs Performance Disclosure - USD ($) $ in Thousands	12 Months Ended
Pay vs Performance Disclosure - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Pay vs Performance Disclosure
Net Income (Loss)	$ (38,966)	$ (53,036)

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+ Details

Related Party Transactions - Additional Information (Details) $ in Millions	12 Months Ended
	Dec. 31, 2025 USD ($)
Research and Development
Related Party Transaction [Line Items]
Stock-based compensation expense	$ 0.6

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

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+ Details

License and Purchase Agreements - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended				12 Months Ended
	Feb. 28, 2025	Jan. 31, 2025	Nov. 30, 2024	Apr. 30, 2023	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2016
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Potential additional cash receipt					$ 65,000
Research and development expense					19,522	$ 46,418
Collaboration revenue					0	4,911
Accrued expenses and other current liabilities					9,143	12,329
BioMarin [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Obligations to pay third party					0
Lilly License Agreement \| Eli Lilly and Company [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Potential additional payment					23,000
Research and development arrangement, costs incurred					0	0
Research and development expense							$ 800
HMNC Agreement \| HMNC Holding GmbH [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Research and development arrangement, costs incurred					0	0
Kaken License Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payments				$ 15,000	15,000
Allievex Purchase Agreement
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Consideration assumed as certain liabilities					8,300
Consideration assumed as accrued expenses and other current liabilities					800
Estimated receivable					2,600
Contingent consideration paid					7,500
Consideration paid			$ 5,000
Aggregate net acquisition cost					11,000	15,100
Sales milestones					100,000
Allievex Purchase Agreement \| Maximum [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development and regulatory milestones					88,000
Allievex Purchase Agreement \| Maximum [Member] \| MPSIIIB [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Development and regulatory milestones					25,500
Allievex Purchase Agreement \| General and administrative expenses [Member]
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Transaction costs						$ 300
HBM Alpha Therapeutics, Inc.
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items]
Upfront payments	$ 5,000
Development and regulatory milestones					390,000
Pre-funded warrants, expiration period		Dec. 31, 2025
Percentage of issued pre-funded warrants		4.99%
Fair value of pre-funded warrants issued					700
Payments to acquire in process research and development					$ 5,000

Fair Value Measurements

12 Months Ended

Dec. 31, 2025

Fair Value Disclosures [Abstract]

Fair Value Measurements

3. Fair Value Measurements

Assets and liabilities measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company classifies money market funds as Level 1 investments as the Company uses quoted prices in active markets for identical assets to determine the fair value. The Company classified its previous warrant liability as a Level 3 instrument as it was valued using the Black-Scholes option pricing model.

The following table summarizes the Company's financial assets measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands):


	December 31, 2025
	Total		Level 1		Level 2		Level 3
Financial assets:
Cash equivalents:
Money market funds	$	48,458	$	48,458	$	—	$	—
Total	$	48,458	$	48,458	$	—	$	—


	December 31, 2024
	Total		Level 1		Level 2		Level 3
Financial assets:
Cash equivalents:
Money market funds	$	37,802	$	37,802	$	—	$	—
Total	$	37,802	$	37,802	$	—	$	—

The Company did not have any financial liabilities recorded at fair value on a recurring basis as of December 31, 2025 and 2024.

HBM Warrant Liability

In January 2025, the Company issued pre-funded warrants that in total were to be equal to 4.99% of the Company's issued and outstanding common stock as of the date of exercise of such pre-funded warrants. See Note 8 “License and Purchase Agreements — HBM Alpha Therapeutics, Inc.” for further discussion regarding such pre-funded warrants. In June 2025, the Company amended these pre-funded warrants to extend the exercise period to December 31, 2025. In December 2025, these pre-funded warrants were fully exercised.

These pre-funded warrants were accounted for as liabilities under ASC 815-40, Derivatives and Hedging, Contracts in Entity’s Own Equity (“ASC 815-40”), as these pre-funded warrants provided for a settlement provision that did not meet the requirements of the indexation guidance under ASC 815-40. These pre-funded warrants were recorded at fair value as a liability. The change in fair value of the warrant liability is included on the face of the statement of operations and comprehensive loss.

These pre-funded warrants were measured using a Black-Scholes option pricing model with the following inputs as of issuance and exercise:


	Grant Date			Exercise Date
Exercise price	$	0.75		$	0.75
Expected term (in years)		0.5		0.0 - 0.1
Risk-free interest rate		4.3	%	3.7% - 3.8%
Expected dividend rate		0.0	%		0.0	%
Expected stock price volatility		65.8	%	75.2% - 132.6%

The following table provides a roll forward of the aggregate fair value of the Company’s warrant liability (in thousands):


	Warrant Liability
Fair value as of December 31, 2024	$	—
Grant date fair value		748
Change in fair value		3,500
Reclass to additional paid-in capital upon exercise		(4,248	)
Fair value as of December 31, 2025	$	—

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References

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+ Details

Related Party Transactions

12 Months Ended

Dec. 31, 2025

Related Party Transactions

14. Related Party Transactions

Effective December 20, 2024, Kirk Ways, M.D., a member of the Board of Directors, began serving as the Company’s interim Chief Medical Officer pursuant to a consulting agreement. During the year ended December 31, 2025, the Company recognized compensation expense of $0.6 million, which is included in research and development expenses on the statement of operations and comprehensive loss.

- Definition

The entire disclosure for related party transactions. Examples of related party transactions include transactions between (a) a parent company and its subsidiary; (b) subsidiaries of a common parent; (c) and entity and its principal owners; and (d) affiliates.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 850
-SubTopic 10
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+ Details

Balance Sheet Components (Tables)

12 Months Ended

Dec. 31, 2025

Balance Sheet Related Disclosures [Abstract]

Schedule of Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):


	December 31,
	2025		2024
Accrued research and development expenses	$	3,496	$	10,635
Accrued general and administrative expenses		3,556		529
Accrued compensation and benefits		1,774		882
Lease liabilities, current portion		317		283
Total accrued expenses and other current liabilities	$	9,143	$	12,329

Balance Sheet Components - Schedule of Accrued Expenses and Other Current Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Balance Sheet Related Disclosures [Abstract]
Accrued research and development expenses	$ 3,496	$ 10,635
Accrued general and administrative expenses	3,556	529
Accrued compensation and benefits	1,774	882
Lease liabilities, current portion	317	283
Total accrued expenses and other current liabilities	$ 9,143	$ 12,329

Net Loss Per Share (Tables)

12 Months Ended

Dec. 31, 2025

Earnings Per Share [Abstract]

Schedule of Computation of Basic and Diluted Net Loss Per Share

The following table sets forth the computation of the basic and diluted net loss per share (in thousands, except share and per share amounts):


	Year Ended December 31,
	2025			2024
Numerator:
Net loss	$	(38,966	)	$	(53,036	)
Denominator:
Weighted-average shares of common stock outstanding		766,598			550,146
Net loss per share, basic and diluted	$	(50.83	)	$	(96.40	)

Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Per Share

Basic net loss per share was the same as diluted net loss per share for all periods as the inclusion of potentially dilutive securities would have been anti-dilutive. Potentially dilutive securities that were not included in the diluted per share calculations were as follows:


	December 31,
	2025		2024
Shares subject to outstanding common stock warrants		169,147		169,154
Shares subject to outstanding common stock options		42,421		46,122
Shares subject to outstanding RSUs		47,200		29,863
Estimated shares issuable under the ESPP		1,228		4,214
Total		259,996		249,353

Fair Value Measurements - Additional Information (Details) - USD ($) $ in Thousands	1 Months Ended
	Jan. 31, 2025	Dec. 31, 2025	Dec. 31, 2024
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Liabilities fair value		$ 0	$ 0
HBM Warrant Liability
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Percentage of issued pre-funded warrants	4.99%
Pre-funded warrants, expiration period	Dec. 31, 2025

Summary of Significant Accounting Policies - Additional Information (Details)	12 Months Ended
	Dec. 31, 2025 USD ($) Segment	Dec. 31, 2024 USD ($)
Summary Of Significant Accounting Policies [Line Items]
Number of operating segment	1
Number of reportable segment	1
Vest period	4 years
Percentage of shares vest	25.00%
Expected lease term	12 months
Impairment losses \| $	$ 0	$ 0
Maximum
Summary Of Significant Accounting Policies [Line Items]
Percentage of tax positions likely of being realized upon ultimate settlement	50.00%

Organization and Principal Activities - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands					12 Months Ended
	Jan. 07, 2026	Oct. 07, 2025	Apr. 29, 2025	Apr. 21, 2025	Dec. 31, 2025	Dec. 31, 2024
Organization And Principal Activities [Line Items]
Common stock, par value					$ 0.0001	$ 0.0001
Percentage of reduction in workforce				55.00%
Termination date				May 02, 2025
Incurred operating expenses					$ 900
Net Income (Loss)					(38,966)	$ (53,036)
Cash in operations					33,300
Accumulated deficit					(289,234)	$ (250,268)
Cash, cash equivalents, and short-term investments					48,900
Loan Agreement with Avenue Capital \| Subsequent Event
Organization And Principal Activities [Line Items]
Gross proceeds	$ 15,000
Research and Development
Organization And Principal Activities [Line Items]
Incurred operating expenses					800
General and Administrative
Organization And Principal Activities [Line Items]
Incurred operating expenses					$ 100
Reverse Stock Split
Organization And Principal Activities [Line Items]
Reverse stock split , shares			75
Private Placement
Organization And Principal Activities [Line Items]
Proceeds from issuance of private placement		$ 50,000
Private Placement \| Common Stock
Organization And Principal Activities [Line Items]
Initial public offering of common stock		502,181
Share price		$ 68
Private Placement \| Pre-Funded Warrants
Organization And Principal Activities [Line Items]
Number of warrants issued					233,144
Purchase price for pre-funded warrants		$ 67.99

Insider Trading Policies and Procedures	12 Months Ended
Insider Trading Policies and Procedures	Dec. 31, 2025
Insider Trading Policies and Procedures [Line Items]
Insider Trading Policies and Procedures Adopted	true

Capital Structure (Tables)

12 Months Ended

Dec. 31, 2025

Equity [Abstract]

Summary of Common Stock Reserved for Future Issuance

Common stock reserved for future issuance, on an as converted basis, consisted of the following:


	December 31,
	2025		2024
Common stock warrants, issued and outstanding		169,147		169,154
Common stock options, issued and outstanding		42,421		46,122
Restricted stock units, issued and outstanding		47,200		29,863
Shares available for future issuance under 2020 Equity Incentive Plan		19,715		27,558
Shares available for future issuance under 2020 Employee Stock Purchase Plan		12,531		12,386
Total shares reserved		291,014		285,083

Fair Value Measurements - Schedule of Pre-funded Warrants Measured Using Black-Scholes Option Pricing Model (Details) - Pre-Funded Warrants	Dec. 31, 2025 shares	Jan. 31, 2025 shares
Exercise price
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants	0.75	0.75
Expected term
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants, Term		6 months
Expected term \| Maximum
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants, Term	1 month 6 days
Expected term \| Minimum
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants, Term	0 years
Risk-free interest rate
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants		0.043
Risk-free interest rate \| Maximum
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants	0.038
Risk-free interest rate \| Minimum
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants	0.037
Expected dividend rate
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants	0	0
Expected stock price volatility
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants		0.658
Expected stock price volatility \| Maximum
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants	1.326
Expected stock price volatility \| Minimum
Fair Value Measurement Inputs and Valuation Techniques [Line Items]
Pre-funded warrants	0.752

Leases - Future Minimum Annual Lease Commitments under Non-cancelable Operating Leases (Detail) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Leases [Abstract]
2026	$ 365
2027	376
2028	64
Total undiscounted operating lease payments	805
Less: present value discount	(69)
Total operating lease liability	736
Lease liabilities, current portion	$ 317
Lease liabilities, net of current portion	Accrued expenses and other current liabilities
Operating lease liability, net of current portion	$ 419	$ 736

Fair Value Measurements (Tables)

12 Months Ended

Dec. 31, 2025

Fair Value Disclosures [Abstract]

Summary of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis

The following table summarizes the Company's financial assets measured at fair value on a recurring basis by level within the fair value hierarchy (in thousands):


	December 31, 2025
	Total		Level 1		Level 2		Level 3
Financial assets:
Cash equivalents:
Money market funds	$	48,458	$	48,458	$	—	$	—
Total	$	48,458	$	48,458	$	—	$	—


	December 31, 2024
	Total		Level 1		Level 2		Level 3
Financial assets:
Cash equivalents:
Money market funds	$	37,802	$	37,802	$	—	$	—
Total	$	37,802	$	37,802	$	—	$	—

Schedule of Pre-funded Warrants Measured Using Black-Scholes Option Pricing Model

These pre-funded warrants were measured using a Black-Scholes option pricing model with the following inputs as of issuance and exercise:


	Grant Date			Exercise Date
Exercise price	$	0.75		$	0.75
Expected term (in years)		0.5		0.0 - 0.1
Risk-free interest rate		4.3	%	3.7% - 3.8%
Expected dividend rate		0.0	%		0.0	%
Expected stock price volatility		65.8	%	75.2% - 132.6%

Schedule of Aggregate Fair Value of Warrant Liability

The following table provides a roll forward of the aggregate fair value of the Company’s warrant liability (in thousands):


	Warrant Liability
Fair value as of December 31, 2024	$	—
Grant date fair value		748
Change in fair value		3,500
Reclass to additional paid-in capital upon exercise		(4,248	)
Fair value as of December 31, 2025	$	—

Net Loss Per Share - Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Per Share (Details) - shares	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potential dilutive securities excluded from diluted net loss per share	259,996	249,353
Shares subject to outstanding common stock warrants
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potential dilutive securities excluded from diluted net loss per share	169,147	169,154
Shares subject to outstanding common stock options
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potential dilutive securities excluded from diluted net loss per share	42,421	46,122
Shares subject to outstanding RSUs
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potential dilutive securities excluded from diluted net loss per share	47,200	29,863
Estimated shares issuable under the ESPP
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potential dilutive securities excluded from diluted net loss per share	1,228	4,214

Net Loss Per Share

12 Months Ended

Dec. 31, 2025

Earnings Per Share [Abstract]

Net Loss Per Share

13. Net Loss Per Share

The following table sets forth the computation of the basic and diluted net loss per share (in thousands, except share and per share amounts):


	Year Ended December 31,
	2025			2024
Numerator:
Net loss	$	(38,966	)	$	(53,036	)
Denominator:
Weighted-average shares of common stock outstanding		766,598			550,146
Net loss per share, basic and diluted	$	(50.83	)	$	(96.40	)


	December 31,
	2025		2024
Shares subject to outstanding common stock warrants		169,147		169,154
Shares subject to outstanding common stock options		42,421		46,122
Shares subject to outstanding RSUs		47,200		29,863
Estimated shares issuable under the ESPP		1,228		4,214
Total		259,996		249,353

Fair Value Measurements - Summary of Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) - Fair Value Recurring - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets, Fair Value Disclosure, Total	$ 48,458	$ 37,802
Money Market Fund
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Cash and cash equivalents, fair value	48,458	37,802
Level 1
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets, Fair Value Disclosure, Total	48,458	37,802
Level 1 \| Money Market Fund
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Cash and cash equivalents, fair value	48,458	37,802
Level 2
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets, Fair Value Disclosure, Total	0	0
Level 2 \| Money Market Fund
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Cash and cash equivalents, fair value	0	0
Level 3
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Assets, Fair Value Disclosure, Total	0	0
Level 3 \| Money Market Fund
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items]
Cash and cash equivalents, fair value	$ 0	$ 0

Subsequent Events - Additional Information (Details) - Subsequent Event	Jan. 07, 2026 USD ($)
Subsequent Event [Line Items]
Long term debt, maturities, repayment terms	The Company will make interest only payments on the Loans until the 12-month anniversary of the Closing Date, subject to (i) a 6-month extension, so long as at least $5.0 million from Tranche 2 has been funded and (ii) an additional 12-month extension if the Company achieves the Tranche 3 milestone.
Commitment fee	$ 400,000
Outstanding principal of the loans	$ 4,000,000
Debt conversion description	Pursuant to the Loan Agreement, upon and following the filing of this Annual Report, the Lender will have the right to convert up to $4.0 million of the outstanding principal of the Loans (the “Conversion Option”) at a price per share equal to 120% of the exercise price of the 2026 Warrant (further discussed below), subject to certain terms and conditions, including beneficial ownership limitations.
Percentage of price per share equal exercise price	120.00%
Financing transactions aggregate amount	$ 1,000,000
2026 Warrant
Subsequent Event [Line Items]
Expiration Date	Jan. 31, 2031
Value of common stock	$ 3,200,000
Lender success fee	$ 6,400,000
Prior to the first anniversary
Subsequent Event [Line Items]
Interest rate of term loan	3.00%
After the first anniversary
Subsequent Event [Line Items]
Interest rate of term loan	2.00%
Prior to the second anniversary
Subsequent Event [Line Items]
Interest rate of term loan	1.00%
After the second anniversary
Subsequent Event [Line Items]
Interest rate of term loan	4.00%
Loan Agreement with Avenue Capital
Subsequent Event [Line Items]
Long term debt	$ 15,000,000
Expiration Date	Jul. 01, 2029
Interest rate of term loan	12.25%
Debt instrument, term	12 months
Loan Agreement with Avenue Capital \| Prime Rate
Subsequent Event [Line Items]
Interest rate of term loan	5.25%
Loan Agreement with Avenue Capital \| Tranche 1
Subsequent Event [Line Items]
Aggregate principal amount	$ 15,000,000
Loan Agreement with Avenue Capital \| Maximum
Subsequent Event [Line Items]
Aggregate principal amount	50,000,000
Loan Agreement with Avenue Capital \| Maximum \| Tranche 2
Subsequent Event [Line Items]
Aggregate principal amount	10,000,000
Loan Agreement with Avenue Capital \| Maximum \| Tranche 3
Subsequent Event [Line Items]
Aggregate principal amount	15,000,000
Loan Agreement with Avenue Capital \| Maximum \| Discretionary Tranche 4
Subsequent Event [Line Items]
Additional term loans	10,000,000
Loan Agreement with Avenue Capital \| Minimum \| Tranche 2
Subsequent Event [Line Items]
Aggregate principal amount	$ 5,000,000

Capital Structure - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2025	Jul. 22, 2025	May 28, 2025	Dec. 31, 2024
Class of Stock [Line Items]
Common stock shares authorized	200,000,000			200,000,000
Common stock, par value	$ 0.0001			$ 0.0001
Common stockholders voting rights	one vote
Common stock dividends declared	$ 0
Preferred Stock, Par Value	$ 0.0001			$ 0.0001
Series A Redeemable Preferred Stock
Class of Stock [Line Items]
Preferred Stock, Par Value			$ 0.0001
Preferred Stock, Share price			$ 100
Preferred stock redemption price per share		$ 100

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

SVB Term Loan

12 Months Ended

Dec. 31, 2025

Debt Disclosure [Abstract]

SVB Term Loan

6. SVB Term Loan

In September 2019, the Company entered into a Loan and Security Agreement, as subsequently amended in March 2021 and May 2022 (the “SVB Loan Agreement”) with Silicon Valley Bank (“SVB”) providing for a term loan (the “SVB Term Loan”) for an aggregate principal amount of $5.0 million.

On November 3, 2025, the Company terminated the SVB Loan Agreement and voluntarily prepaid in full the outstanding principal balance of the SVB Term Loan and all other outstanding obligations under the SVB Loan Agreement, which was $0.7 million, inclusive of all principal and all accrued and unpaid interest and fees under the SVB Loan Agreement.

- Definition

The entire disclosure for information about short-term and long-term debt arrangements, which includes amounts of borrowings under each line of credit, note payable, commercial paper issue, bonds indenture, debenture issue, own-share lending arrangements and any other contractual agreement to repay funds, and about the underlying arrangements, rationale for a classification as long-term, including repayment terms, interest rates, collateral provided, restrictions on use of assets and activities, whether or not in compliance with debt covenants, and other matters important to users of the financial statements, such as the effects of refinancing and noncompliance with debt covenants.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 815
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 8A
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480434/815-10-50-8A

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480738/235-10-S50-1

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(c))
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147480678/235-10-S99-1

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481544/470-10-50-6

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 6
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481544/470-10-50-6

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 405
-SubTopic 40
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147477092/405-40-50-1

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 405
-SubTopic 40
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)(3)
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 405
-SubTopic 40
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 405
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-Name Accounting Standards Codification
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-Paragraph 1
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-URI https://asc.fasb.org/1943274/2147477092/405-40-50-1

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 405
-SubTopic 40
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Subparagraph (a)
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-URI https://asc.fasb.org/1943274/2147477092/405-40-50-1

Reference 11: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 1B
-Subparagraph (h)
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481139/470-20-50-1B

Reference 12: http://fasb.org/us-gaap/role/ref/legacyRef
-Topic 470
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org/470/tableOfContent

Reference 13: http://www.xbrl.org/2003/role/disclosureRef
-Topic 835
-SubTopic 30
-Name Accounting Standards Codification
-Section 45
-Paragraph 2
-Publisher FASB
-URI https://asc.fasb.org/1943274/2147482925/835-30-45-2

Reference 14: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
-SubTopic 20
-Name Accounting Standards Codification
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481139/470-20-50-1B

Reference 15: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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Reference 16: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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Reference 17: http://www.xbrl.org/2003/role/disclosureRef
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Reference 18: http://www.xbrl.org/2003/role/disclosureRef
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-URI https://asc.fasb.org/1943274/2147481139/470-20-50-1C

Reference 19: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-Name Accounting Standards Codification
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Reference 20: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-URI https://asc.fasb.org/1943274/2147481139/470-20-50-1E

Reference 21: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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Reference 22: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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Reference 23: http://www.xbrl.org/2003/role/disclosureRef
-Topic 470
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-Paragraph 1I
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-Publisher FASB
-URI https://asc.fasb.org/1943274/2147481139/470-20-50-1I

+ Details

Leases - Additional Information (Details) - South San Francisco, California $ in Thousands	1 Months Ended	12 Months Ended
	Dec. 31, 2022 USD ($) ft²	Dec. 31, 2025
Lessee, Lease, Description [Line Items]
Area of office space \| ft²	6,500
Operating lease commencement date	2022-12
Operating lease termination date	2028-02
Total minimum rental payments	$ 1,700
Operating Leases, option to renew lease term description		The Company has an option to extend the lease term of the South San Francisco Lease for an additional three years which has not been included in the lease term as it is not reasonably certain that the Company will exercise this option.
Operating leases, renew lease term	3 years
letter of credit issued	$ 29
Collateralized by a restricted cash deposit	$ 36

Income Taxes - Schedule of Reconciliation of Beginning and Ending Balance of Unrecognized Tax Benefits (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Income Tax Disclosure [Abstract]
Balance at the beginning of the year	$ 4,348	$ 3,240
Increases based on tax positions related to current period	179	870
Increases based on tax positions related to prior period	0	365
Decreases based on tax positions related to prior period	(3,752)	(127)
Balance at the end of the year	$ 775	$ 4,348

Stock-Based Compensation - Summary of RSU Activity (Details) - RSU - $ / shares	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Shares, Unvested, Beginning Balance	29,863
Shares, Granted	45,306
Shares, Vested	(22,300)
Shares, Forfeited	(5,669)
Shares, Unvested, Ending Balance	47,200	29,863
Weighted Average Grant Date Fair Value Per Share, Beginning Balance	$ 108.12
Weighted Average Grant Date Fair Value Per Share, Granted	85.35	$ 119.27
Weighted Average Grant Date Fair Value Per Share, Vested	82.89
Weighted Average Grant Date Fair Value Per Share, Forfeited	198.41
Weighted Average Grant Date Fair Value Per Share, Ending Balance	$ 87.33	$ 108.12

Income Taxes - Schedule of Reconciliation of the Federal Statutory Income Tax Rate to Effective Tax Rate (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Income Tax Disclosure [Abstract]
U.S. federal taxes at statutory rate	$ (8,183)
Loss on fair value of warrant liability	735
Nondeductible expenses related to tax credits	780
Credits	(3,713)
Section 383 limitation - credits	35,143
Other	193
Change in valuation allowance	(21,441)
Deferred tax true ups	154
Changes in unrecognized tax benefits	(3,668)
Effective tax rate	$ 0	$ 0
U.S. federal taxes at statutory rate	21.00%	21.00%
Nondeductible items		(2.90%)
Loss on fair value of warrant liability	(1.90%)
Nondeductible expenses related to tax credits	(2.00%)
Credits	9.50%	17.90%
Section 383 limitation - credits	(90.20%)
Other	(0.40%)
Change in valuation allowance	55.00%	(34.30%)
Prior year true up		(1.70%)
Deferred tax true ups	(0.40%)
Changes in unrecognized tax benefits	9.40%
Effective tax rate	0.00%	0.00%

Stock-Based Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions		1 Months Ended	12 Months Ended
	Jan. 01, 2026	Oct. 31, 2020	Dec. 31, 2025	Dec. 31, 2024
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares reserved for future issuance			291,014	285,083
Aggregate intrinsic value of options exercised			$ 0.3	$ 0.3
Options vested in period, fair value			$ 9.3	$ 2.1
Weighted-average fair value of options granted			$ 50.72	$ 48.06
Unrecognized stock-based compensation expense			$ 3.5
RSU
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted Average Grant Date Fair Value Per Share			$ 85.35	$ 119.27
RSUs granted			45,306
Number of RSUs outstanding			47,200	29,863
Fair value of RSUs vested in period			$ 1.8	$ 2.8
Weighted Average Grant Date Fair Value Per Share, Granted			$ 85.35	$ 119.27
Unrecognized stock-based compensation expense expected to be recognized over weighted-average vesting term			1 year 9 months 18 days
Performance Based Vesting \| RSU
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Number of RSUs outstanding			2,970
Probable of Achievement \| RSU
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
RSUs granted			0
2020 Equity Incentive Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Term of automatically increase in common stock available for issuance		10 years
Percentage of outstanding shares subject to automatic increase in common stock		5.00%
Equity incentive plans terms			The number of shares of common stock available for issuance under the 2020 Plan will be automatically increased on the first day of each calendar year during the ten-year term of the 2020 Plan, beginning with January 1, 2021 and ending with January 1, 2030, by an amount equal to 5% of the outstanding number of shares of the Company’s common stock on December 31st of the preceding calendar year or such lesser amount as determined by the Company’s Board of Directors. As of December 31, 2025, 19,715 shares remained available for issuance under the 2020 Plan. On January 1, 2026, shares available for issuance under the 2020 Plan were automatically increased by 68,602 shares.
Total stock options outstanding			42,421
Shares remained available for issuance			19,715
Number of options outstanding			42,421	46,122
2020 Equity Incentive Plan \| Subsequent Event
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Shares remained available for issuance	68,602
2020 Employee Stock Purchase Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Term of automatically increase in common stock available for issuance		10 years
Percentage of outstanding shares subject to automatic increase in common stock		1.00%
Equity incentive plans terms			The number of shares of common stock available for issuance under the ESPP will be automatically increased on the first day of each calendar year during the first ten-years of the term of the ESPP, beginning with January 1, 2021 and ending with January 1, 2030, by an amount equal to the lessor of (i) 1% of the outstanding number of shares of the Company’s common stock on December 31st of the preceding calendar year, (ii) 5,883 shares of common stock or (iii) such lesser amount as determined by the Board of Directors.
Shares remained available for issuance			12,531
Shares subject to repurchase upon early exercise of options			0
Maximum percentage of compensation that an employee is allowed to purchase shares		15.00%
Purchase price of common stock expressed as a percentage of fair market value		85.00%
Employee stock purchase plan offering period			provides for 24-month offering periods starting every January 1st and July 1st, each consisting of four six-month purchase periods
2020 Employee Stock Purchase Plan \| Subsequent Event
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Increase in shares available for grant	5,883

Leases

12 Months Ended

Dec. 31, 2025

Leases [Abstract]

Leases

5. Leases

The Company leases space under a non-cancelable operating lease, which requires the Company to pay base rent, real estate taxes, insurance, general repairs, and maintenance.

In December 2022, the Company entered into a non-cancelable operating lease for approximately 6,500 square feet of office space in South San Francisco, California, which commenced in December 2022 and expires in February 2028 (the “South San Francisco Lease”). Total minimum rental payments for the South San Francisco Lease are $1.7 million over the lease term. The Company has an option to extend the lease term of the South San Francisco Lease for an additional three years which has not been included in the lease term as it is not reasonably certain that the Company will exercise this option. The Company will also be responsible for the payment of additional rent to cover the Company's share of the annual operating and tax expense for the building. Under the terms of the South San Francisco Lease, the Company issued a letter of credit to the landlord of $29 thousand, which is collateralized by a restricted cash deposit of $36 thousand as of December 31, 2025.

Other information related to the operating lease was as follows (dollar amounts in thousands):


	Year Ended December 31,
	2025			2024
Operating lease costs	$	337		$	336
Cash paid for operating lease liabilities	$	354		$	344
Weighted average remaining lease term (years)		2.2			3.2
Weighted average discount rate		8.0	%		8.0	%

Variable lease expense for the years ended December 31, 2025 and 2024 was immaterial.

Future minimum lease commitments under the Company’s leases as of December 31, 2025 were as follows (in thousands):


Year ending December 31,
2026		365
2027		376
2028		64
Total undiscounted lease payments		805
Less: present value discount		(69	)
Total lease liabilities	$	736
Lease liabilities, current portion*	$	317
Lease liabilities, net of current portion		419
Total lease liabilities	$	736

* included in accrued expenses and other current liabilities on the balance sheets

Document and Entity Information - USD ($) $ in Millions	12 Months Ended
Document and Entity Information - USD ($) $ in Millions	Dec. 31, 2025	Mar. 03, 2026	Jun. 30, 2025
Cover [Abstract]
Document Type	10-K
Amendment Flag	false
Document Period End Date	Dec. 31, 2025
Document Fiscal Year Focus	2025
Document Fiscal Period Focus	FY
Entity Registrant Name	Spruce Biosciences, Inc.
Entity Central Index Key	0001683553
Entity Current Reporting Status	Yes
Entity Voluntary Filers	No
Entity Interactive Data Current	Yes
Current Fiscal Year End Date	--12-31
Entity Filer Category	Non-accelerated Filer
Entity Well-known Seasoned Issuer	No
Entity Public Float			$ 2.8
Entity Common Stock, Shares Outstanding		1,372,043
Document Financial Statement Error Correction [Flag]	false
Entity Shell Company	false
Entity Small Business	true
Entity Emerging Growth Company	false
Title of 12(b) Security	Common Stock, par value $0.0001 per share
Trading Symbol	SPRB
Security Exchange Name	NASDAQ
Entity File Number	001-39594
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	81-2154263
Entity Address, Address Line One	611 Gateway Boulevard
Entity Address, Address Line Two	Suite 740
Entity Address, City or Town	South San Francisco
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94080
City Area Code	415
Local Phone Number	343-5986
Document Annual Report	true
Document Transition Report	false
ICFR Auditor Attestation Flag	false
Documents Incorporated by Reference	Portions of the Registrant’s definitive Proxy Statement for its 2026 Annual Meeting of Stockholders to be filed with the Securities and Exchange Commission pursuant to Regulation 14A not later than 120 days after the end of the fiscal year covered by this Annual Report on Form 10-K are incorporated by reference into Part III of this Annual Report on Form 10-K.
Auditor Name	BDO USA, P.C.
Auditor Location	San Jose, California
Auditor Firm ID	243
Auditor Opinion [Text Block]	Opinion on the Financial Statements We have audited the accompanying balance sheets of Spruce Biosciences, Inc. (the “Company”) as of December 31, 2025 and 2024, the related statements of operations and comprehensive loss, stockholders’ equity, and cash flows for each of years then ended and the related notes (collectively referred to as the “financial statements”). In our opinion, the financial statements present fairly, in all material respects, the financial position of the Company at December 31, 2025 and 2024, and the results of its operations and its cash flows for the years then ended, in conformity with accounting principles generally accepted in the United States of America. Going Concern Uncertainty The accompanying financial statements have been prepared assuming that the Company will continue as a going concern. As discussed in Note 1 to the financial statements, the Company has incurred significant losses and negative cash flows from operations and does not expect positive cash flows from operations in the foreseeable future, that raise substantial doubt about its ability to continue as a going concern. Management’s plans in regard to these matters are also described in Note 1. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.

Commitments and Contingencies - Additional Information (Details) $ in Millions	1 Months Ended
	Feb. 28, 2026 USD ($)	Dec. 31, 2025 USD ($)	Jan. 31, 2025 Patent
Loss Contingencies [Line Items]
Number of patent \| Patent			3,784,233
Loss contingency, accrual, current		$ 1.9
Subsequent Event
Loss Contingencies [Line Items]
Legal costs	$ 1.2

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 275
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+ Details

License and Purchase Agreements

12 Months Ended

Dec. 31, 2025

Research and Development [Abstract]

License and Purchase Agreements

8. License and Purchase Agreements

Eli Lilly and Company

In May 2016, the Company entered into a license agreement (the “Lilly License Agreement”), with Eli Lilly and Company (“Lilly”). Pursuant to the terms of the Lilly License Agreement, Lilly granted the Company an exclusive, worldwide, royalty bearing, sublicensable license under certain technology, patent rights, know-how and proprietary materials related to certain compounds, to research, develop, and commercialize such compounds for all pharmaceutical uses.

As partial consideration for the rights granted to the Company under the Lilly License Agreement, the Company made a one-time upfront payment to Lilly of $0.8 million during the year ended December 31, 2016, which was recorded as research and development expense as there was no alternative use due to the early stage of the technology. The Company is also required to pay Lilly up to an aggregate of $23.0 million upon the achievement, during the time the Lilly License Agreement remains in effect, of certain milestones relating to the clinical development and commercial sales of products licensed under the Lilly License Agreement. Such payments are for predetermined fixed amounts, are paid only upon the first occurrence of each event, and are due shortly after achieving the applicable milestone. In addition, the Company is required to pay Lilly tiered royalties on annual worldwide net sales with rates ranging from mid-single-digits to sub-teens. No amounts were paid by the Company to Lilly during the years ended December 31, 2025 and 2024, nor were due as of such dates pursuant to the Lilly License Agreement.

The Lilly License Agreement will remain in effect, unless earlier terminated, until the expiration of the royalty payment obligations. Royalties are payable on a product-by-product and country-by-country basis from the first commercial sale of the product until the later of (i) the tenth anniversary of the date of first commercial sale in such country, (ii) the expiration in such country of the last-to-expire licensed patent having a valid claim covering the manufacture, use or sale of the licensed product as commercialized in such country, and (iii) the expiration of any data or regulatory exclusivity period for the licensed product in such country.

HMNC Holding GmbH

In May 2024, the Company entered into a license, development and option agreement (the “HMNC Agreement”) with HMNC Holding GmbH (“HMNC”). Under the terms of the HMNC Agreement, HMNC funded and conducted a Phase 2 proof-of-concept study of tildacerfont in MDD patients, who were screened using Cortibon Genetic Selection Tool (“Cortibon”), HMNC’s proprietary genetic selection tool.

The study was discontinued in the first quarter of 2026. The Company has an option to in-license exclusive worldwide rights to Cortibon. . If the Company exercises its option, it will be responsible for the future worldwide development and commercialization of tildacerfont and Cortibon for the treatment of MDD under a collaboration framework that leverages HMNC’s ongoing expertise in precision psychiatry and companion diagnostics. Pursuant to the license terms, HMNC would be entitled to receive certain milestone payments and tiered royalties on net sales of tildacerfont in MDD.

No amounts were paid to the Company during the years ended December 31, 2025 and 2024, nor were due as of such dates pursuant to the HMNC Agreement.

Allievex Corporation

On October 4, 2024, the Company entered into that certain Asset Purchase Agreement (the “Allievex Purchase Agreement”) with AVX (ABC), LLC, a Delaware limited liability company, in its sole and limited capacity as the assignee for the benefit of creditors of Allievex Corporation (“Allievex”). Pursuant to the Allievex Purchase Agreement, the Company acquired all intellectual property and inventory relating to Allievex's product candidates and that certain Exclusive License Agreement, by and between BioMarin Pharmaceutical Inc. (“BioMarin”) and Allievex, dated October 22, 2019 (the “BioMarin License Agreement”).

As consideration, the Company paid $5.0 million to Allievex in November 2024. The Company also assumed certain liabilities of Allievex of $8.3 million, of which $7.5 million was paid as of December 31, 2025 and the remaining $0.8 million is included in accrued expenses and other current liabilities on the balance sheet as of December 31, 2025. The Company also recorded an estimated receivable of $2.6 million in other current assets on the balance sheet as of December 31, 2025 related to the completed Allievex bankruptcy proceedings. The receivable was fully collected by the Company in January 2026. The Company also incurred transaction costs of $0.3 million during the year ended December 31, 2024, which were included in general and administrative expenses on the statement of operations and comprehensive loss.

The Company concluded that the assets purchased in conjunction with the Allievex Purchase Agreement represent an asset acquisition whereby the underlying assets comprise in-process research and development assets with no alternative future use. The Company recognized aggregate net acquisition cost of $15.1 million, which was reported as a component of research and development expense for the year ended December 31, 2024. During the year ended December 31, 2025, changes in estimates to recorded liabilities associated with the Allievex Purchase Agreement reduced the aggregate net acquisition cost to $11.0 million.

The Company also assumed the obligations of Allievex to pay BioMarin up to an aggregate of $88.0 million upon the achievement of certain development and regulatory milestones (up to $25.5 million for the first MPS IIIB product) and up to an aggregate of $100.0 million per licensed product upon the achievement of certain sales milestones. In addition, the Company is required to pay to BioMarin certain (i) high-single digit to low-double digit tiered royalties on aggregate annual net sales of licensed MPS IIIB products and (i) mid-to-high single digit tiered royalties on aggregate annual net sales of licensed products other than MPS IIIB products, in each case during the applicable royalty term, subject to certain customary reductions and floors. No amounts were paid by the Company to BioMarin nor were any due as of December 31, 2025 pursuant to the Allievex Purchase Agreement.

The Company may terminate the BioMarin License Agreement at any time for convenience upon prior written notice provided within a specified period of time. BioMarin may terminate the BioMarin License Agreement upon written notice if we (i) challenge the validity, enforceability or scope of any of the patents licensed by us under the BioMarin License Agreement, subject to certain conditions, or (ii) cease all material research and development activity for any licensed product for a specified period of time, subject to certain exceptions. Either the Company or BioMarin may also terminate the BioMarin License Agreement (i) in the event the other party shall have materially breached its obligations thereunder and such default shall have continued for a specified period after written notice thereof or (ii) upon the bankruptcy or insolvency of the other party.

HBM Alpha Therapeutics, Inc.

On January 15, 2025, the Company entered into a collaboration and license agreement (the “HBM License Agreement”) with HBM Alpha Therapeutics, Inc. (“HBM”). Under the terms of the HBM License Agreement, HBM granted the Company a limited exclusivity, royalty bearing, and sublicensable license to certain technology, patent rights, manufacturing rights, know-how, and proprietary materials relating to certain compounds developed by HBM.

As consideration, the Company made a one-time upfront payment to HBM of $5.0 million in February 2025. Additionally, in January 2025, the Company issued pre-funded warrants to HBM and its affiliates that in total were to be equal to 4.99% of the Company's outstanding common stock as of the date of exercise of such pre-funded warrants. In June 2025, the Company amended the pre-funded warrants to extend the exercise period to December 2025. In December 2025, these pre-funded warrants were fully exercised.

The Company concluded that the rights acquired under the HBM License Agreement have no alternative future use. Therefore, the consideration paid of $5.0 million, along with the initial fair value of the pre-funded warrants issued of $0.7 million (see Note 3 “Fair Value Measurements — Warrant Liability”), was recognized as acquired in-process research and development expense, which is reported as a component of research and development expense for the year ended December 31, 2025.

The Company is also obligated to pay HBM up to an aggregate of $390.0 million upon the achievement of certain development, regulatory, and sales milestones. In addition, the Company is required to pay to HBM certain mid to high-single digit tiered royalties on aggregate annual net sales of licensed products during the applicable royalty term, subject to certain customary reductions.

The Company may terminate the HBM License Agreement on a licensed product-by-licensed product basis or

in its entirety at any time for convenience upon prior written notice provided within a specified period of time. Either the Company or HBM may also terminate the HBM License Agreement (i) in the event the other party shall have materially breached its obligations thereunder and such default shall have continued for a specified period after written notice thereof or (ii) upon the bankruptcy or insolvency of the other party. HBM may terminate the HBM License Agreement upon prior written notice if the Company (i) ceases all development or commercialization activities for a specified period of time, subject to certain exceptions, or (ii) challenges the validity, enforceability or scope of any of the patents licensed by the Company to HBM under the HBM License Agreement, subject to certain conditions.

Kaken Pharmaceutical Co. Ltd.

On January 5, 2023, the Company entered into a collaboration and license agreement (the “Kaken License Agreement”) with Kaken Pharmaceutical Co. Ltd. (“Kaken”). Under the terms of the Kaken License Agreement, the Company granted to Kaken the exclusive right to develop, manufacture and commercialize the Company’s product candidate, tildacerfont, for the treatment of CAH in Japan. Pursuant to the Kaken License Agreement, Kaken is responsible for securing and maintaining regulatory approvals necessary to commercialize tildacerfont in Japan. The Company will retain all rights to tildacerfont in all other geographies.

Pursuant to the Kaken License Agreement, Kaken made an upfront payment to the Company of $15.0 million in April 2023. In addition to the upfront payment, the Company is entitled to receive up to an aggregate of approximately $65.0 million (at exchange rates in effect on the date of the Kaken License Agreement) upon the achievement of specified milestones related to the development, regulatory approval and commercialization of tildacerfont in Japan, including the achievement of specified net sales thresholds, if approved. Kaken has agreed to pay the Company a non-creditable, non-refundable specified purchase price for each unit of Company-manufactured product supplied to Kaken for commercial sale. In addition, the Company will also be entitled to receive a royalty for each unit of non-Company manufactured product sold equal to a range of double-digit percentages up to the mid-twenties based on annual net sales of tildacerfont in Japan. Both the purchase price for each unit and the royalty rate are subject to reduction in certain circumstances as specified in the Kaken License Agreement. Kaken’s obligation to pay royalties will continue for ten years after the first commercial sale in Japan or, if later, until the expiration of regulatory exclusivity of tildacerfont or the expiration of the last valid claim of a Company-licensed patent covering tildacerfont in Japan.

The Company identified a combined performance obligation consisting of the license and know-how granted to Kaken as well as certain non-contingent research and development activities. The Company determined that the transaction price at the inception of the Kaken License Agreement consisted of the upfront payment of $15.0 million. The transaction price was recognized as revenue using the cost-based input method over the estimated period of its non-contingent research and development obligations, which was approximately two years. During the year ended December 31, 2024, the Company recognized collaboration revenue of $4.9 million. The transaction price was fully recognized as of December 31, 2024 as the performance obligation was satisfied.

Capital Structure - Summary of Common Stock Reserved for Future Issuance (Details) - shares	Dec. 31, 2025	Dec. 31, 2024
Class Of Stock [Line Items]
Shares reserved for future issuance	291,014	285,083
Shares available for future issuance under 2020 Employee Stock Purchase Plan
Class Of Stock [Line Items]
Shares reserved for future issuance	12,531	12,386
Common stock warrants, issued and outstanding
Class Of Stock [Line Items]
Shares reserved for future issuance	169,147	169,154
Common stock options, issued and outstanding
Class Of Stock [Line Items]
Shares reserved for future issuance	42,421	46,122
Restricted stock units, issued and outstanding
Class Of Stock [Line Items]
Shares reserved for future issuance	47,200	29,863
Shares available for future issuance under 2020 Equity Incentive Plan
Class Of Stock [Line Items]
Shares reserved for future issuance	19,715	27,558

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

401(k) Retirement Savings Plan

12 Months Ended

Dec. 31, 2025

Retirement Benefits [Abstract]

401(k) Retirement Savings Plan

12. 401(k) Retirement Savings Plan

In December 2017, the Company adopted a plan under Section 401(k) of the Internal Revenue Code (the “401(k) Plan”) for all employees who have met certain eligibility requirements. Under the 401(k) Plan, employees may elect to contribute a portion of their eligible compensation, subject to certain limitations. During the years ended December 31, 2025 and 2024, the Company incurred expense of $0.1 million.

- Definition

The entire disclosure for retirement benefits.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Fair Value Measurements - Schedule of Aggregate Fair Value of Warrant Liability (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Fair Value Disclosures [Abstract]
Fair value as of December 31, 2024	$ 0
Grant date fair value	748
Change in fair value	3,500	$ 0
Reclass to additional paid-in capital upon exercise	(4,248)
Fair value as of December 31, 2025	$ 0	$ 0

Leases - Other information related to operating leases (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Leases [Abstract]
Operating lease costs	$ 337	$ 336
Cash paid for operating lease liabilities	$ 354	$ 344
Weighted average remaining lease term (years)	2 years 2 months 12 days	3 years 2 months 12 days
Weighted average discount rate	8.00%	8.00%

Capital Structure

12 Months Ended

Dec. 31, 2025

Equity [Abstract]

Capital Structure

9. Capital Structure

Common Stock

As of December 31, 2025 and 2024, the Company was authorized to issue 200,000,000 shares of $0.0001 par value common stock, respectively. Holders of the Company’s common stock are entitled to dividends if and when declared by the Board of Directors of the Company (“Board of Directors”). The holder of each share of common stock is entitled to one vote. As of December 31, 2025, no dividends were declared.

Common stock reserved for future issuance, on an as converted basis, consisted of the following:


	December 31,
	2025		2024
Common stock warrants, issued and outstanding		169,147		169,154
Common stock options, issued and outstanding		42,421		46,122
Restricted stock units, issued and outstanding		47,200		29,863
Shares available for future issuance under 2020 Equity Incentive Plan		19,715		27,558
Shares available for future issuance under 2020 Employee Stock Purchase Plan		12,531		12,386
Total shares reserved		291,014		285,083

Redeemable Preferred Stock

On May 28, 2025, the Company entered into a Purchase Agreement with Michael Grey, the Executive Chairman of the Company’s Board of Directors, pursuant to which the Company issued and sold one share of the Company’s newly designated Series A Preferred Stock, par value $0.0001 per share (the “Series A Preferred”), to Mr. Grey for a purchase price of $100.00. On July 22, 2025, immediately following stockholder approval of the Reverse Stock Split (as defined in Note 1), the outstanding share of Series A Preferred was redeemed for a redemption price of $100.00.

- Definition

The entire disclosure for equity.

+ References

+ Details

Leases (Tables)

12 Months Ended

Dec. 31, 2025

Leases [Abstract]

Other Information Related to Operating Leases

Other information related to the operating lease was as follows (dollar amounts in thousands):


	Year Ended December 31,
	2025			2024
Operating lease costs	$	337		$	336
Cash paid for operating lease liabilities	$	354		$	344
Weighted average remaining lease term (years)		2.2			3.2
Weighted average discount rate		8.0	%		8.0	%

Future Minimum Annual Lease Commitments Under Non-cancelable Operating Leases

Future minimum lease commitments under the Company’s leases as of December 31, 2025 were as follows (in thousands):


Year ending December 31,
2026		365
2027		376
2028		64
Total undiscounted lease payments		805
Less: present value discount		(69	)
Total lease liabilities	$	736
Lease liabilities, current portion*	$	317
Lease liabilities, net of current portion		419
Total lease liabilities	$	736

* included in accrued expenses and other current liabilities on the balance sheets

Organization and Principal Activities

12 Months Ended

Dec. 31, 2025

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Organization and Principal Activities

1. Organization and Principal Activities

Description of Business

Spruce Biosciences, Inc. (the “Company”) is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for neurological disorders with significant unmet medical need. The Company is located in South San Francisco, California and was incorporated in the state of Delaware in April 2016.

Reverse Stock Split

Effective April 29, 2025, the Company’s common stock was delisted from Nasdaq as a result of the Company’s ongoing failure to comply with the minimum bid price requirement under Nasdaq. As a result, the Company’s common stock began trading publicly on the over-the-counter market on April 29, 2025 under its symbol “SPRB”.

Subsequently, the Company effected a one-for-seventy-five (1:75) reverse stock split of its outstanding common stock (the “Reverse Stock Split”). The Company's common stock began trading on the OTCQB on a split-adjusted basis on August 7, 2025 (the “Split Effective Date”) under the ticker symbol “SPRBD”. The Company’s common stock resumed trading on the Nasdaq Capital Market on September 15, 2025 under the ticker symbol “SPRB”.

At the Split Effective Date, every 75 shares of the Company’s issued and outstanding common stock were automatically converted into one issued and outstanding share of common stock, without any change in authorized common stock or par value per share. The Reverse Stock Split affected all shares of the Company’s common stock outstanding immediately prior to the effective time of the Reverse Stock Split, as well as the number of shares of common stock available for issuance under the Company’s equity incentive plans and employee stock purchase plan. In addition, the Reverse Stock Split effected a reduction in the number of shares of common stock issuable upon the exercise of warrants, stock options and restricted stock units outstanding immediately prior to the effectiveness of the Reverse Stock Split with a corresponding increase in the exercise price per share applicable to such warrants and stock options. No fractional shares were issued because of the Reverse Stock Split. Stockholders who were otherwise entitled to receive a fractional share received a cash payment in lieu thereof.

All of the outstanding common stock share numbers (including shares of common stock subject to the Company’s options), share prices, exercise prices and per share amounts contained in the financial statements have been retroactively adjusted in the financial statements to reflect this Reverse Stock Split for all periods presented.

Private Placement of Common Stock and Pre-Funded Warrants

On October 7, 2025, the Company entered into a Securities Purchase Agreement with certain institutional investors to sell and issue (i) 502,181 shares of the Company’s common stock and (ii) pre-funded warrants to purchase up to 233,144 shares of the Company’s common stock in a private placement transaction, which were exercised in full by December 31, 2025. The purchase price per share of common stock was $68.00 per share and the purchase price for the pre-funded warrants was $67.99. The private placement transaction closed on October 9, 2025. The total gross proceeds to the Company were $50.0 million, before deducting placement agent fees and other expenses.

Reduction in Force

On April 21, 2025, the Company effected a workforce reduction of 55% to prioritize development and potential accelerated approval of tralesinidase alfa enzyme replacement therapy (“TA-ERT”) for the treatment of Sanfilippo Syndrome Type B (“MPS IIIB”). The workforce reduction was effective immediately, with a termination date of May 2, 2025 for affected individuals. During the year ended December 31, 2025, the Company incurred total operating expenses of $0.9 million in connection with the workforce reduction, consisting of expenses related to severance payments and healthcare coverage assistance and related costs. Of the total expense, $0.8 million was included in research and development expenses and $0.1 million in general and administrative expenses on the statement of operations and comprehensive loss during the year ended December 31, 2025. The workforce reduction was completed as of June 30, 2025.

Liquidity and Capital Resources

The Company has incurred significant losses and negative cash flows from operations. During the year ended December 31, 2025, the Company incurred a net loss of $39.0 million and used $33.3 million of cash in operations. As of December 31, 2025, the Company had an accumulated deficit of $289.2 million and does not expect positive cash flows from operations in the foreseeable future. The Company has funded its operations primarily through the issuance and sale of equity securities, debt and collaboration revenue.

The accompanying financial statements have been prepared assuming the Company will continue as a going concern, which assumes the realization of assets and satisfaction of liabilities and commitments in the normal course of business. Without alternative financing or proceeds from other strategic alternatives, the Company believes that based on its current operating plan, its cash and cash equivalents of $48.9 million as of December 31, 2025 and gross proceeds of $15.0 million received in January 2026 under the Loan Agreement with Avenue Capital (see Note 15), will be insufficient to fund its planned operations and debt obligations for at least 12 months following the issuance date of these financial statements. The Company’s ability to continue as a going concern will require the Company to raise additional capital to fund the Company's operations and there can be no assurance that additional financing will be available to the Company or that such financing, if available, will be available on terms acceptable to the Company. Accordingly, there is substantial doubt about the Company’s ability to continue as a going concern for at least 12 months following the issuance date of these financial statements.

In order to meet these additional cash requirements, the Company may seek to out-license rights to develop and commercialize its investigational product candidates or sell additional equity or issue debt, convertible debt or other securities that may result in dilution to its stockholders. If the Company raises additional funds through the issuance of debt or convertible debt securities, these securities could have rights senior to those of its shares of common stock and could contain covenants that restrict its operations. There can be no assurance that the Company will be able to obtain additional equity or debt financing on terms acceptable to it, if at all. Additional debt financing, if available, would result in increased fixed payment obligations and may involve agreements that include covenants limiting or restricting the Company’s ability to take specific actions such as incurring debt, making capital expenditures or declaring dividends. The Company’s failure to obtain sufficient funds on acceptable terms when needed could have a material adverse effect on its business, results of operations, financial condition and prospects.

Stock-Based Compensation - Summary of Stock Option Activity - 2020 Equity Incentive Plan (Details) - 2020 Equity Incentive Plan - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Beginning Balance, Outstanding Stock Options	46,122
Granted, Outstanding Stock Options	6,200
Exercised, Outstanding Stock Options	(61)
Forfeited, Outstanding Stock Options	(9,840)
Ending Balance, Outstanding Stock Options	42,421	46,122
Vested and expected to vest, Outstanding Stock Options	42,421
Vested and exercisable, Outstanding Stock Options	36,295
Beginning Balance, Weighted-Average Exercise Price	$ 244.42
Granted, Weighted-Average Exercise Price	52.56
Exercised, Weighted-Average Exercise Price	88.5
Forfeited, Weighted-Average Exercise Price	122.58
Ending Balance, Weighted-Average Exercise Price	244.86	$ 244.42
Vested and expected to vest, Weighted-Average Exercise Price	244.86
Vested and exercisable, Weighted-Average Exercise Price	$ 273.46
Weighted-Average Remaining Contractual Life (Years)	5 years 10 months 24 days	6 years 8 months 12 days
Vested and expected to vest, Weighted-Average Remaining Contractual Life (Years)	5 years 10 months 24 days
Vested and exercisable, Weighted-Average Remaining Contractual Life (Years)	5 years 3 months 18 days
Aggregate Intrinsic Value	$ 264	$ 0
Vested and expected to vest, Aggregate Intrinsic Value	264
Vested and exercisable, Aggregate Intrinsic Value	$ 108

Stock-Based Compensation - Schedule of Weighted-Average Assumptions to Estimate Fair Value of Stock Options and Purchase Rights Under ESPP Using the Black-Scholes Option-Pricing Model (Details)	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expected term (in years)	5 years 3 months 18 days	5 years 6 months
Expected volatility	159.30%	118.10%
Risk-free interest rate	3.80%	4.50%
Expected dividend rate	0.00%	0.00%
2020 Employee Stock Purchase Plan
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expected term (in years)	1 year 4 months 24 days	1 year 4 months 24 days
Expected volatility	154.00%	222.80%
Risk-free interest rate	4.10%	5.10%
Expected dividend rate	0.00%	0.00%

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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-Section 50
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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-Section 50
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-Subparagraph (f)(2)(i)
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 5: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 11: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Stock-Based Compensation - Summary of Stock-Based Compensation Expense Related to Stock Options, RSUs and ESPP (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	$ 2,574	$ 5,348
Research and Development
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	(72)	2,013
General and Administrative
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Total stock-based compensation expense	$ 2,646	$ 3,335

BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Current assets:
Cash and cash equivalents	$ 48,906	$ 38,753
Prepaid expenses	353	3,177
Other current assets	2,853	2,276
Total current assets	52,112	44,206
Right-of-use assets	666	934
Other assets	243	69
Total assets	53,021	45,209
Current liabilities:
Accounts payable	943	1,295
Accrued expenses and other current liabilities	9,143	12,329
Term loan, current portion	0	1,622
Total current liabilities	10,086	15,246
Lease liabilities, net of current portion	419	736
Term loan, net of current portion	0	124
Other liabilities	0	282
Total liabilities	10,505	16,388
Commitments and contingencies (Note 7)
Stockholders' equity:
Preferred stock, $0.0001 par value; 10,000,000 shares authorized and no shares issued or outstanding as of December 31, 2025 and 2024	0	0
Common stock, $0.0001 par value; 200,000,000 shares authorized as of December 31, 2025 and 2024; 1,372,043 and 563,042 shares issued and outstanding as of December 31, 2025 and 2024, respectively	0	0
Additional paid-in capital	331,750	279,089
Accumulated deficit	(289,234)	(250,268)
Total stockholders' equity	42,516	28,821
Total liabilities and stockholders' equity	$ 53,021	$ 45,209

Income Taxes - Schedule of Significant Components of Net Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Deferred tax assets:
Net operating loss carryforwards	$ 44,720	$ 35,484
Tax credits	2,396	29,808
Capitalized research costs	13,224	15,518
Stock based compensation	1,557	1,164
Lease liability	193	214
Accruals and reserves	913	696
Intangible assets	4,693	2,617
Other	3,258	45
Total gross deferred tax assets	70,954	85,546
Valuation allowance	(70,777)	(85,349)
Total deferred tax assets	177	197
Deferred tax liabilities:
Lease right-of-use asset	(175)	(196)
Property and equipment	(2)	(1)
Total deferred tax liabilities	$ (177)	$ (197)

STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Income Statement [Abstract]
Collaboration revenue	$ 0	$ 4,911
Operating expenses:
Research and development	19,522	46,418
General and administrative	16,991	14,644
Total operating expenses	36,513	61,062
Loss from operations	(36,513)	(56,151)
Interest expense	(90)	(307)
Change in fair value of warrant liability	(3,500)	0
Interest and other income, net	1,137	3,422
Net loss and comprehensive loss	$ (38,966)	$ (53,036)
Net loss per share, basic	$ (50.83)	$ (96.4)
Net loss per share, diluted	$ (50.83)	$ (96.4)
Weighted-average shares of common stock outstanding, basic	766,598	550,146
Weighted-average shares of common stock outstanding, diluted	766,598	550,146

Balance Sheet Components

12 Months Ended

Dec. 31, 2025

Balance Sheet Related Disclosures [Abstract]

Balance Sheet Components

4. Balance Sheet Components

Accrued Expenses and Other Current Liabilities

Accrued expenses and other current liabilities consisted of the following (in thousands):


	December 31,
	2025		2024
Accrued research and development expenses	$	3,496	$	10,635
Accrued general and administrative expenses		3,556		529
Accrued compensation and benefits		1,774		882
Lease liabilities, current portion		317		283
Total accrued expenses and other current liabilities	$	9,143	$	12,329

Accrued research and development expenses were primarily related to clinical trials and manufacturing of clinical drug supply as well as accruals related to the Allievex asset purchase. See Note 8 “License and Purchase Agreements — Allievex Corporation” for further information regarding such asset purchase.

Summary of Significant Accounting Policies

12 Months Ended

Dec. 31, 2025

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

2. Summary of Significant Accounting Policies

Basis of Presentation

The financial statements and accompanying notes have been prepared in accordance with generally accepted accounting principles in the United States (“U.S. GAAP”) and include all adjustments necessary for the fair presentation of the Company’s financial position for the periods presented.

Use of Estimates

The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities and expenses as well as related disclosure of contingent assets and liabilities. Significant estimates and assumptions reflected in these financial statements include, but are not limited to, accrued research and development expenses, stock-based compensation, and uncertain tax positions. The Company bases its estimates on its historical experience and on assumptions that it believes are reasonable; however, actual results could significantly differ from those estimates.

Risks and Uncertainties

Any product candidates developed by the Company will require approvals from the U.S. Food and Drug Administration or foreign regulatory agencies prior to commercial sales. There can be no assurance that the Company’s current and future product candidates will meet desired efficacy and safety requirements to obtain the necessary approvals. If approval is denied or delayed, it may have a material adverse impact on the Company’s business and its financial statements.

The Company is subject to a number of risks similar to other late-stage biopharmaceutical companies including, but not limited to, dependency on the clinical success of the Company’s product candidates, ability to obtain regulatory approval of its product candidates, the need for substantial additional financing to achieve its goals, uncertainty of broad adoption of its approved products, if any, by physicians and consumers, significant competition, untested manufacturing capabilities, and dependence on key individuals and sole source suppliers.

Global economic and business activities continue to face widespread macroeconomic and geopolitical uncertainties, including global trade disputes, labor shortages, declines in consumer confidence, inflation and monetary supply shifts, recession risks, potential disruptions from the ongoing wars in Ukraine and the Middle East and related sanctions, declines in economic growth, tariffs and related legal challenges, the recent U.S. government shutdown and uncertainty about economic stability. The Company continues to actively monitor the impact of these macroeconomic and geopolitical factors on its financial condition, liquidity, operations, and workforce. The extent of the impact of these factors on the Company’s operational and financial performance, including its ability to execute its business strategies and initiatives in the expected time frame, will depend on future developments, which are uncertain and cannot be predicted; however, any continued or renewed disruption resulting from these factors could negatively impact the Company’s business.

Concentration of Credit Risk

Financial instruments, which potentially subject the Company to significant concentration of credit risk, consist primarily of cash and cash equivalents. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits. The Company is exposed to credit risk in the event of default by the financial institutions holding its cash and cash equivalents to the extent recorded in the balance sheets.

Segment Reporting

The Company operates and manages its business as one reportable and operating segment, which is the business of developing and commercializing novel therapies for serious neurological and disorders with significant unmet medical need. The Company’s chief executive officer, who is the chief operating decision maker (“CODM”), reviews financial information on an aggregate basis for allocating and evaluating financial performance. All long-lived assets are maintained in the United States of America.

The Company's prior year segment revenue is derived from a collaboration and license agreement with Kaken Pharmaceutical Co, Ltd. The CODM assesses performance and decides how to allocate resources based on net loss. Net loss is used to monitor budget versus actual results. The measure of segment revenue, segment net loss and segment expenses is reported on the statement of operations. The measure of segment assets is reported on the balance sheet as total assets.

Cash and Cash Equivalents

The Company considers all highly liquid investments with remaining maturities at the date of purchase of three months or less to be cash equivalents. Cash equivalents, which consist of amounts invested in money market funds, are stated at fair value.

Restricted Cash

The Company's restricted cash is related to collateralized cash in connection with letters of credit issued on behalf of the Company for the security deposit required under an operating lease. Restricted cash is included in other assets on the balance sheets and is included in the reconciliation of cash, cash equivalents, and restricted cash on the statements of cash flows.

Fair Value of Financial Instruments

Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability, or an exit price, in the principal or most advantageous market for that asset or liability in an orderly transaction between market participants on the measurement date. Fair value measurement establishes a fair value hierarchy that requires an entity to maximize the use of observable inputs, where available, and minimize the use of unobservable inputs when measuring fair value.

The Company determined the fair value of financial assets and liabilities using the fair value hierarchy that describes three levels of inputs that may be used to measure fair value, as follows:

▪

Level 1—Quoted prices in active markets for identical assets and liabilities;

▪

Level 2—Inputs other than Level 1 that are observable, either directly or indirectly, such as quoted prices for similar assets or liabilities, quoted prices in markets that are not active, or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities; and

▪

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

The Company’s financial instruments primarily consist of cash and cash equivalents, prepaid expenses, accounts payable, warrant liability and accrued expenses. The carrying value of cash and cash equivalents, prepaid expenses, accounts payable and accrued expenses are generally considered to be representative of their respective fair values because of the short-term nature of those instruments. The estimated fair value of the warrant liability was based on the Black-Scholes option pricing model, which was considered a Level 3 fair value measurement.

Leases

The Company determines if an arrangement includes a lease at inception. Right-of-use assets and lease liabilities are recognized based on the present value of the future minimum lease payments over the lease term at the commencement date. The right-of-use asset includes any lease payments made on or before the lease commencement date, less lease incentives received. The incremental borrowing rate is used in determining the present value of future payments. The Company utilizes its incremental borrowing rate, which is the rate incurred to borrow on a collateralized basis over a similar term an amount equal to the lease payments in a similar economic environment. The lease terms may include options to extend or terminate the lease. Lease expense for operating leases is recognized on a straight-line basis over the non-cancelable lease term. Variable lease expense relates primarily to office lease common area maintenance, insurance, and property taxes, is expensed as incurred, and is excluded from the calculation of the lease liability and right-of-use-asset.

The Company has elected not to recognize a right-of-use asset and lease liability for short-term leases. A short-term lease is a lease with an expected lease term of 12 months or less and which does not include an option to purchase the underlying asset that the lessee is reasonably certain to exercise. Lease agreements that include lease and non-lease components are accounted for as a single lease component.

Property and Equipment, Net

Property and equipment are stated at cost less accumulated depreciation and are included in other assets on the balance sheets. Depreciation expense is calculated using the straight-line method over the estimated useful life of the respective asset and begins at the time the asset is placed into service. Maintenance and repairs are charged to expense as incurred, and improvements are capitalized.

The useful lives of property and equipment are as follows:


Computer and office equipment	3 years
Computer software	3 years
Furniture and fixtures	5 years
Manufacturing machinery and equipment	7 years

Long-Lived Assets

Long-lived assets, such as property and equipment are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of an asset may not be fully recoverable. If circumstances require a long-lived asset or asset group to be tested for possible impairment, the Company first compares undiscounted cash flows expected to be generated by that asset or asset group to its carrying value. If the carrying value of the long-lived asset or asset group is not recoverable on an undiscounted cash flow basis, an impairment is recognized to the extent that the carrying value exceeds its fair value. Fair value is determined through various valuation techniques including discounted cash flow models, quoted market values and third-party independent appraisals, as considered necessary. There were no such impairment losses during the years ended December 31, 2025 and 2024.

Accrued Research and Development Expenses

Clinical trial costs are charged to research and development expense as incurred. The Company accrues for expenses resulting from contracts with clinical research organizations (“CROs”), consultants, and clinical site agreements in connection with conducting clinical trials. The financial terms of these contracts are subject to negotiations, which vary from contract to contract and may result in payment flows that do not match the periods over which materials or services are provided to us under such contracts. The Company’s policy is to reflect the appropriate expense in the financial statements by matching the appropriate expenses with the period in which services and efforts are expended.

The CRO contracts generally include pass-through fees including, but not limited to, regulatory expenses, investigator fees, laboratory fees and other miscellaneous costs. The Company determines accrual estimates through reports from and discussion with clinical personnel and outside service providers as to the progress or state of completion of trials, or the services completed. The Company estimates accrued expenses as of each balance sheet date based on the facts and circumstances known at that time. The clinical trial accrual is dependent, in part, upon the receipt of timely and accurate reporting from the CROs and other third-party vendors.

If the actual timing of the performance of services or the level of effort varies from the original estimates, the Company will adjust the accrual accordingly. Payments associated with licensing agreements to acquire exclusive licenses to develop, use, manufacture and commercialize products that have not reached technological feasibility and do not have alternate commercial use are expensed as incurred. Payments made to third parties under these arrangements in advance of the performance of the related services by the third parties are recorded as prepaid expenses until the services are rendered.

Revenue Recognition

The Company recognizes revenues when, or as, the promised goods or services are transferred to customers in an amount that reflects the consideration to which the Company expects to be entitled in exchange for those services. To determine revenue recognition for arrangements, the Company performs the following five steps: (1) identify the contract(s) with a customer; (2) identify the performance obligation(s) in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligation(s) in the contract; and (5) recognize revenue when (or as) the performance obligation(s) are satisfied.

The Company previously entered into a licensing and collaboration agreement that primarily included the following: (i) upfront cash consideration; (ii) payments associated with achieving certain milestones; and (iii) royalties based on specified percentages of net product sales, if any. At the initiation of an agreement, the Company analyzes each unit of account within the contract to determine if the counterparty is a customer in the context of the unit of account.

At contract inception, the Company assesses the goods or services promised and enforceable in a contract with a customer and identifies those distinct goods and services that represent a performance obligation. If a promised good or service is not distinct, the Company combines that good or service with other promised goods or services until it identifies a bundle of goods or services that is distinct. Promised goods and services that are not material in the context of the contract are not considered performance obligations. Additional goods or services that are exercisable at a customer’s discretion are assessed to determine if they provide a material right to the customer and if so, they are considered performance obligations.

The transaction price is the amount of consideration to which the Company expects to be entitled in exchange for transferring promised goods or services to a customer. The consideration promised in a contract with a customer

may include fixed amounts, variable amounts, or both. Non-refundable upfront payments are considered fixed consideration and included in the transaction price. At the inception of arrangements that include variable consideration, the Company uses judgment to estimate the amount of variable consideration to include in the transaction price using the most likely method. If it is probable that a significant revenue reversal will not occur, then the estimated amount is included in the transaction price. Milestone payments that are not within the Company’s or the licensee’s control, such as regulatory approvals, are not included in the transaction price until those approvals are received. For arrangements with licenses of intellectual property that include sales-based royalties, including milestone payments based on the level of sales, and if the license is deemed to be the predominant item to which the royalties relate, the Company recognizes royalty revenue and sales-based milestones at the later of (i) when the related sales occur, or (ii) when the performance obligation to which the royalty has been allocated has been satisfied. At the end of each reporting period, the Company re-evaluates the estimated variable consideration included in the transaction price and any related constraint and, as necessary, adjusts the estimate of the overall transaction price. Any adjustments will be recorded on a cumulative catch-up basis, which would affect revenues and earnings in the period of adjustment.

If it is determined that multiple performance obligations exist, the transaction price is allocated at the inception of the agreement to all identified performance obligations based on the relative standalone selling prices, unless the consideration is variable and meets the criteria to be allocated entirely to one or more, but not all, performance obligations in the contract. Other components of the transaction price are allocated based on the relative standalone selling price, over which the Company applies significant judgment. The Company develops assumptions that require judgment to determine the standalone selling price for license-related performance obligations under the adjusted market assessment approach, which may include forecasted revenues, development timelines, discount rates and probabilities of success.

Revenue is recognized when, or as, the Company satisfies a performance obligation. The Company recognizes revenue over time by measuring the progress toward complete satisfaction of the relevant performance obligation using an appropriate input method based on the nature of the good or service promised to the customer. The Company uses judgment to assess the nature of the performance obligation to determine whether the performance obligation is satisfied over time or at a point in time. The selection of the method to measure progress towards completion requires judgment and is based on the nature of the products or services to be provided.

If a customer pays consideration, or the Company has an unconditional right to the consideration, before the satisfaction of the revenue recognition criteria, the amounts are recorded as deferred revenue in the Company’s balance sheet. The current portion of deferred revenue represents the amount of the performance obligation that is expected to be satisfied within the next twelve months. Amounts recognized as revenue prior to receipt or before they are due are recorded as contract assets in the Company’s balance sheet, excluding any amounts presented as accounts receivable. If the Company has an unconditional right to receive consideration, the contract assets are accounted for as accounts receivable and presented separately from contract assets. A net contract asset or liability is presented for each contract with a customer.

Research and Development Expenses

Research and development costs are expensed as incurred. Research and development expenses include, but are not limited to, purchases of acquired in-process research and development, personnel costs, fees paid to external entities that conduct certain non-clinical and clinical development activities on our behalf, manufacturing costs, outside service and consulting costs, and allocated overhead, including rent. Assets acquired that are utilized in research and development that have no alternative future use are also expensed as incurred. Purchases of acquired in-process research and development are included as an operating activity on the statements of cash flow.

Stock-Based Compensation

The Company accounts for stock-based compensation using a fair value-based method, which requires the recognition of compensation expense for costs related to all stock-based payments including stock options, restricted stock units (“RSUs”) and purchase rights under the Employee Stock Purchase Plan (“ESPP”). The Company estimates the fair value of stock options and purchase rights granted under the ESPP on the date of grant using the Black-Scholes option pricing model, which is impacted by the fair value of the Company’s common stock, as well as changes in assumptions regarding a number of variables. The model requires management to make a number of assumptions which include the following:

▪

Expected Term. The expected term is based on the simplified method as the Company’s stock options qualify as “plain vanilla” options and the Company has limited history of exercise data. For ESPP, the expected term is based on the term of the purchase period.

▪

Expected Volatility. The expected volatility is based on the historical volatility of the Company's stock.

▪

Risk-Free Interest Rate. The risk-free interest rate is based on U.S. Treasury constant maturity rates with remaining terms similar to the expected term of the options.

▪

Expected Dividend Rate. The Company has never paid any dividends and does not plan to pay dividends in the foreseeable future, and, therefore, used an expected dividend rate of zero in the valuation model.

▪

Forfeitures. The Company accounts for forfeitures as they occur.

The fair value of RSUs, including RSUs subject to performance-based vesting conditions, is based on the fair value of the Company's stock price on the grant-date.

The Company recognizes compensation expense on a straight-line basis over the requisite service period of the award, which is generally the vesting period. The Company accounts for forfeitures as they occur.

Options generally vest over a four-year period: 25% of the shares vest on the first anniversary from the vesting commencement date of the option and an additional 1/48th of the shares vest on each monthly anniversary thereafter, subject to the employee’s continuous service through each vesting date. RSUs generally vest ratably over four years.

For options and RSUs that vest upon the satisfaction of certain performance conditions, the Company recognizes compensation expense when it becomes probable that the performance conditions will be met. When the criteria are deemed probable of being met, the Company records cumulative compensation expense in the period the performance criteria are deemed probable of being met and recognizes the remaining compensation expense on a straight-line basis over the remaining period for which the performance criteria are expected to be completed.

Income Taxes

The Company accounts for income taxes under the asset and liability method. The Company estimates actual current tax exposure together with assessing temporary differences resulting from differences in accounting for reporting purposes and tax purposes for certain items, such as accruals and allowances not currently deductible for tax purposes. These temporary differences result in deferred tax assets and liabilities. In general, deferred tax assets represent future tax benefits to be received when certain expenses previously recognized in the Company’s statements of operations and comprehensive loss become deductible expenses under applicable income tax laws or when net operating loss or credit carryforwards are utilized. Accordingly, realization of the Company’s deferred tax assets is dependent on future taxable income against which these deductions, losses and credits can be utilized.

The Company assesses the likelihood that the Company’s deferred tax assets will be recovered from future taxable income, and to the extent the Company believes that recovery is not likely, the Company establishes a valuation allowance. The assessment of whether or not a valuation allowance is required often requires significant judgment, including the forecast of future taxable income and on-going prudent and feasible tax planning initiatives. Based upon the weight of available evidence, the Company has determined that net deferred tax assets should be fully offset by a valuation allowance. When the Company establishes or reduces the valuation allowance against its net deferred tax assets, its provision for income taxes will increase or decrease, respectively, in the period such determination is made.

The Company accounts for uncertainty in income taxes in accordance with Accounting Standards Codification (“ASC”) 740. Tax positions are evaluated in a two-step process, whereby the Company first determines whether it is more likely than not that a tax position will be sustained upon examination by tax authorities, including resolutions of any related appeals or litigation processes, based on technical merit. If a tax position meets the more-likely-than-not recognition threshold, it is then measured to determine the amount of benefit to be recognized in the financial statements. The tax position is measured as the largest amount of benefit that is greater than 50% likely of being realized upon ultimate settlement. The Company’s policy is to recognize interest and penalties related to the underpayment of income taxes as a component of income tax expense or benefit. To date, there have been no interest or penalties charged in relation to unrecognized tax benefits.

Comprehensive Loss

Comprehensive loss is equal to net loss as there are no components of other comprehensive loss.

Net Loss per Share

Basic net loss per share attributable to common stockholders is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period including any outstanding pre-funded warrants, without consideration for potentially dilutive securities. Diluted net loss per share attributable to common stockholders is computed by dividing the net loss attributable to common stockholders by the weighted-average number of common stock and potentially dilutive securities outstanding for the period. For purposes of the diluted net loss per share calculation, outstanding stock options, RSUs, outstanding common stock warrants and shares expected to be issued pursuant to the ESPP are considered to be potentially dilutive securities. Because the Company has reported a net loss for all periods presented, diluted net loss per share is the same as basic net loss per share for those periods.

Recent Accounting Pronouncements Adopted

In December 2023, the Financial Accounting Standards Board (the “FASB”) issued Accounting Standards Update 2023-09, Income Taxes - Improvements to Income Tax Disclosures (“ASU 2023-09”) requiring enhancements and further transparency to certain income tax disclosures, most notably the tax rate reconciliation and income taxes paid. ASU 2023-09 does not change the recognition or measurement of income taxes under ASC 740. The Company adopted ASU 2023-09 on a prospective basis for the fiscal year ended December 31, 2025 and other than the presentation of additional disaggregated data in the income tax footnote disclosure, there was no material impact on the Company's financial statements. Prior-period comparative disclosures for the income tax footnote have not been recast to the expanded format required by ASU 2023-09, consistent with the transition guidance in ASU 2023-09.

Recent Accounting Pronouncements - Not Yet Adopted

In November 2024, the FASB issued Accounting Standards Update 2024-03, Income Statement-Reporting Comprehensive Income-Expense Disaggregation Disclosures (Subtopic 220-40): Disaggregation of Income Statement Expenses (“ASU 2024-03”), which requires disaggregated information about certain income statement expense line items on an annual and interim basis. ASU 2024-03 is effective for annual periods beginning after December 15, 2026 and interim reporting periods within annual reporting periods beginning after December 15, 2027. Early adoption is permitted and can be applied prospectively or retrospectively. The Company is evaluating the impact of the adoption of this standard on the Company’s financial statements and related disclosures.

Income Taxes

12 Months Ended

Dec. 31, 2025

Income Tax Disclosure [Abstract]

Income Taxes

11. Income Taxes

The Company did not have any income tax expense for the years ended December 31, 2025 and 2024. The reconciliation of the federal statutory income tax rate to the Company’s effective tax rate is as follows:


	December 31,
	2025
	Amount			Percentage
U.S. federal taxes at statutory rate	$	(8,183	)		21.0		%
Nontaxable and nondeductible items:
Loss on fair value of warrant liability		735			(1.9	)
Nondeductible expenses related to tax credits		780			(2.0	)
Credits		(3,713	)		9.5
Section 383 limitation - credits		35,143			(90.2	)
Other		193			(0.4	)
Change in valuation allowance		(21,441	)		55.0
Deferred tax true ups		154			(0.4	)
Changes in unrecognized tax benefits		(3,668	)		9.4
Effective tax rate	$	—			—		%


	December 31,
	2024
U.S. federal taxes at statutory rate		21.0		%
Nondeductible items		(2.9	)
Tax credits		17.9
Change in valuation allowance		(34.3	)
Prior year true up		(1.7	)
Effective tax rate		—		%

Upon adoption of ASU 2023-09 for the year ended December 31, 2025, the Company expanded its income tax rate reconciliation disclosures to conform to the enhanced presentation requirements of the standard. As a result, certain reconciling items that were previously aggregated are now presented as separate categories in the rate reconciliation. For the year ended December 31, 2024, amounts reflected in the rate reconciliation were presented on a combined basis, including the impact of unrecognized tax benefits, which was included within tax credits. The prior-period presentation has not been recast to conform to the current-period presentation.

Deferred Tax Assets and Liabilities

Deferred income taxes reflect the net tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes. Significant components of the Company’s net deferred tax assets and liabilities are as follows (in thousands):


	December 31,
	2025			2024
Deferred tax assets:
Net operating loss carryforwards	$	44,720		$	35,484
Tax credits		2,396			29,808
Capitalized research costs		13,224			15,518
Stock based compensation		1,557			1,164
Lease liability		193			214
Accruals and reserves		913			696
Intangible assets		4,693			2,617
Other		3,258			45
Total gross deferred tax assets		70,954			85,546
Valuation allowance		(70,777	)		(85,349	)
Total deferred tax assets		177			197
Deferred tax liabilities:
Lease right-of-use asset		(175	)		(196	)
Property and equipment		(2	)		(1	)
Total deferred tax liabilities		(177	)		(197	)
Total net deferred tax assets	$	—		$	—

Management regularly assesses the ability to realize deferred tax assets recorded based upon the weight of available evidence, including such factors as recent earnings history and expected future taxable income on a jurisdiction by jurisdiction basis. In the event that the Company changes its determination as to the amount of realizable deferred tax assets, the Company will adjust its valuation allowance with a corresponding impact to the provision for income taxes in the period in which such determination is made. The Company’s management believes that, based on a number of factors, it is more likely than not, that all or some portion of the deferred tax assets will not be realized; and accordingly, for the year ended December 31, 2025, the Company has provided a valuation allowance against the Company’s U.S. net deferred tax assets. The valuation allowance decreased by $14.6 million during the year ended December 31, 2025, primarily due to the impact of Internal Revenue Code Section 382 ownership change limitations on the Company's tax attributes including research and development and Orphan Drug credits offset by an increase in net operating loss due to the election to expense Section 174 research and development costs in the current year. The valuation allowance increased by $18.2 million during the year ended December 31, 2024, primarily due to an increase in the net operating loss (primarily from pre-tax book loss) and the current year capitalization of Section 174 research and experimental costs.

As of December 31, 2025, the Company had net operating loss carryforwards for federal and state income tax purposes of approximately $163.1 million and $150.0 million, respectively, both of which will begin to expire in 2036 with $155.9 million of the Company's federal net operating loss carryforwards lasting indefinitely.

As of December 31, 2025, the Company had general business credit and state research and development credit carryforwards of approximately $34.2 million and $2.8 million, respectively. The federal general business credit carryforwards will begin to expire in 2036 while the California research credit carryforwards have an indefinite life.

The Internal Revenue Code of 1986, as amended, imposes restrictions on the utilization of net operating losses in the event of an “ownership change” of a corporation. Accordingly, a company’s ability to use net operating losses may be limited as prescribed under Internal Revenue Code Section 382 (“IRC Section 382”). Events which may cause limitations in the amount of the net operating losses that the Company may use in any one year include, but are not limited to, a cumulative ownership change of more than 50% over a three-year period. Utilization of the federal and state net operating losses may be subject to substantial annual limitation due to the ownership change limitations provided by the IRC Section 382 and similar state provisions. The Company identified an ownership change in October 2025 and performed an analysis on potential limitations under IRC Section 382. The Company does not believe there is a limitation on its ability to utilize its net operating losses from the October 2025 ownership change.

As a result of the ownership change identified in October of 2025, the Company analyzed potential limitations on the Company's tax attributes. Based on this analysis, the Company wrote off the deferred tax assets related to its

research and development credits and Orphan Drug credits to the extent that they are mathematically impossible to utilize with the calculated limitations under Section 382/383. Research and development credits of $1.8 million and $33.3 million of Orphan Drug credits were written off during the year ended December 31, 2025.

The Company files income tax returns in the U.S. federal jurisdiction and California state jurisdiction. The Company is not currently under audit by the Internal Revenue Service or any other similar state, local, or foreign authority. All tax years remain open to examination by major taxing jurisdictions to which the Company is subject.

Uncertain Income Tax Positions

The Company had approximately $0.8 million and $4.3 million of unrecognized tax benefits as of December 31, 2025 and 2024, respectively. No liability related to uncertain tax positions is recorded in the financial statements due to the fact the liabilities have been netted against deferred attribute carryovers. The unrecognized tax benefits would not impact the annual effective tax rate if recognized because the Company has recorded a valuation allowance on its deferred tax assets. The Company does not expect the amount of unrecognized tax benefits to materially change in the next 12 months. As of December 31, 2025 and 2024, the Company has not recognized any tax-related penalties or interest in its financial statements.

A reconciliation of the beginning and ending balance of the unrecognized tax benefits is as follows (in thousands):


	December 31,
	2025			2024
Balance at the beginning of the period	$	4,348		$	3,240
Increases based on tax positions related to current period		179			870
Increases based on tax positions related to prior period		—			365
Decreases based on tax positions related to prior period		(3,752	)		(127	)
Balance at the end of the period	$	775		$	4,348

- Definition

The entire disclosure for income tax.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 942
-SubTopic 740
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 3: http://www.xbrl.org/2003/role/disclosureRef
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Reference 4: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://www.xbrl.org/2003/role/disclosureRef
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Reference 12: http://www.xbrl.org/2003/role/disclosureRef
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Reference 13: http://www.xbrl.org/2003/role/disclosureRef
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Reference 14: http://www.xbrl.org/2003/role/disclosureRef
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Reference 15: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Net Loss Per Share - Schedule of Computation of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
Numerator:
Net Income (Loss)	$ (38,966)	$ (53,036)
Denominator:
Weighted-average shares of common stock outstanding, basic	766,598	550,146
Weighted-average shares of common stock outstanding, diluted	766,598	550,146
Net loss per share, basic	$ (50.83)	$ (96.4)
Net loss per share, diluted	$ (50.83)	$ (96.4)

- Definition

The amount of net income (loss) for the period per each share of common stock or unit outstanding during the reporting period.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 260
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+ Details

- Definition

The amount of net income (loss) for the period available to each share of common stock or common unit outstanding during the reporting period and to each share or unit that would have been outstanding assuming the issuance of common shares or units for all dilutive potential common shares or units outstanding during the reporting period.

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+ Details

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

+ Details

Summary of Significant Accounting Policies - Schedule of Useful Lives of Property and Equipment (Details)	Dec. 31, 2025
Computer and Office Equipment
Property, Plant and Equipment [Line Items]
Property and equipment, useful Lives	3 years
Computer Software
Property, Plant and Equipment [Line Items]
Property and equipment, useful Lives	3 years
Furniture and Fixtures
Property, Plant and Equipment [Line Items]
Property and equipment, useful Lives	5 years
Manufacturing Machinery and Equipment
Property, Plant and Equipment [Line Items]
Property and equipment, useful Lives	7 years

Income Taxes (Tables)

12 Months Ended

Dec. 31, 2025

Income Tax Disclosure [Abstract]

Schedule of Reconciliation of the Federal Statutory Income Tax Rate to Effective Tax Rate

The reconciliation of the federal statutory income tax rate to the Company’s effective tax rate is as follows:


	December 31,
	2025
	Amount			Percentage
U.S. federal taxes at statutory rate	$	(8,183	)		21.0		%
Nontaxable and nondeductible items:
Loss on fair value of warrant liability		735			(1.9	)
Nondeductible expenses related to tax credits		780			(2.0	)
Credits		(3,713	)		9.5
Section 383 limitation - credits		35,143			(90.2	)
Other		193			(0.4	)
Change in valuation allowance		(21,441	)		55.0
Deferred tax true ups		154			(0.4	)
Changes in unrecognized tax benefits		(3,668	)		9.4
Effective tax rate	$	—			—		%


	December 31,
	2024
U.S. federal taxes at statutory rate		21.0		%
Nondeductible items		(2.9	)
Tax credits		17.9
Change in valuation allowance		(34.3	)
Prior year true up		(1.7	)
Effective tax rate		—		%

Schedule of Significant Components of Net Deferred Tax Assets and Liabilities

Significant components of the Company’s net deferred tax assets and liabilities are as follows (in thousands):


	December 31,
	2025			2024
Deferred tax assets:
Net operating loss carryforwards	$	44,720		$	35,484
Tax credits		2,396			29,808
Capitalized research costs		13,224			15,518
Stock based compensation		1,557			1,164
Lease liability		193			214
Accruals and reserves		913			696
Intangible assets		4,693			2,617
Other		3,258			45
Total gross deferred tax assets		70,954			85,546
Valuation allowance		(70,777	)		(85,349	)
Total deferred tax assets		177			197
Deferred tax liabilities:
Lease right-of-use asset		(175	)		(196	)
Property and equipment		(2	)		(1	)
Total deferred tax liabilities		(177	)		(197	)
Total net deferred tax assets	$	—		$	—

Schedule of Reconciliation of Beginning and Ending Balance of Unrecognized Tax Benefits

A reconciliation of the beginning and ending balance of the unrecognized tax benefits is as follows (in thousands):


	December 31,
	2025			2024
Balance at the beginning of the period	$	4,348		$	3,240
Increases based on tax positions related to current period		179			870
Increases based on tax positions related to prior period		—			365
Decreases based on tax positions related to prior period		(3,752	)		(127	)
Balance at the end of the period	$	775		$	4,348

401(k) Retirement Savings Plan - Additional Information (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024
401(K) Plan
Defined Benefit Plan Disclosure [Line Items]
Employer contribution plan expense incurred	$ 0.1	$ 0.1

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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+ Details

Cybersecurity Risk Management, Strategy and Governance	12 Months Ended
Cybersecurity Risk Management, Strategy and Governance	Dec. 31, 2025
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]	Item 1C. Cybersecurity. Risk Management and Strategy We have implemented and maintain various information security processes designed to identify, assess and manage material risks from cybersecurity threats to our critical computer networks, third party hosted services, communications systems, hardware and software, and our critical data, including intellectual property, confidential information that is proprietary, strategic or competitive in nature, and personal health information (including clinical trial data) (“Information Systems and Data”). Our information technology function, which is led by Samir Gharib, our President, Chief Financial Officer, and Chief Compliance Officer, helps identify, assess and manage the Company’s cybersecurity threats and risks. Our information technology function works to identify and assess risks from cybersecurity threats by monitoring and evaluating our threat environment and the Company’s risk profile using various methods including, employing both automated and manual tools and controls; conducting threat and vulnerability assessments; utilizing third-party services to monitor our information technology infrastructure; and performing internal audits. Depending on the environment, we implement and maintain various technical, physical, and organizational measures, processes, standards and policies designed to manage and mitigate material risks from cybersecurity threats to our Information Systems and Data, including, for example: risk assessments, incident detection and response policies, network security controls for certain systems (including as applicable data segregation, data encryption, access controls, physical security, and systems threat monitoring), disaster recovery and business continuity plans, vendor risk management program, and dedicated cybersecurity staff and employee training. Our assessment and management of material risks from cybersecurity threats are integrated into the Company’s overall risk management processes. For example, cybersecurity risk is addressed as a component of the Company’s enterprise risk management program and the information technology function works with management to prioritize our risk management processes and mitigate cybersecurity threats that are more likely to lead to a material impact to our business. Additionally, Mr. Gharib and the audit committee of the board of directors evaluate material risks from cybersecurity threats against our overall business objectives and reports to the board of directors, which evaluates our overall enterprise risk. We use third-party service providers to assist us from time to time to identify, assess, and manage material risks from cybersecurity threats, including for example cybersecurity software providers and managed cybersecurity service providers. We use third-party service providers to perform a variety of functions throughout our business, such as application providers, hosting companies, contract research organizations, contract manufacturing organizations, and supply chain providers. We have a vendor management program to manage cybersecurity risks associated with our use of service providers. The program includes, as applicable, risk assessment for certain vendors, security questionnaires, review of certain vendors’ security programs and security assessments, and imposition of cybersecurity-related contractual obligations for some vendors. Depending on the nature of the services provided, the sensitivity of the Information Systems and Data at issue, and the identity of the provider, our vendor management process may involve different levels of assessment designed to help identify cybersecurity risks associated with a provider and we may impose contractual obligations related to cybersecurity on the provider. For a description of the risks from cybersecurity threats that may materially affect the Company and how they may do so, see our risk factors under Part 1. Item 1A. Risk Factors in this Annual Report, including the sections titled “Risk Factors—If our information technology systems or data, or those of third parties with whom we work, are or were compromised, we could experience adverse consequences resulting from such compromise, including but not limited to regulatory investigations or actions; litigation; fines and penalties; disruptions of our business operations; reputational harm; loss of revenue or profits; and other adverse consequences” and “Risk Factors—We and the third parties with whom we work are subject to stringent and evolving U.S. and foreign laws, regulations, and rules; contractual obligations; industry standards; policies; and other obligations, in each case related to data privacy or security. Our (or the third parties with whom we work) actual or perceived failure to comply with such obligations could lead to regulatory investigations and actions (which could include civil or criminal penalties); private litigation (including class-action claims) and mass arbitration demands; disruptions to our business operations; adverse publicity; and other adverse business consequences.” Governance Our board of directors addresses the Company’s cybersecurity risk management as part of its general oversight function. The audit committee of the board of directors is responsible for overseeing Company’s cybersecurity risk management processes, including oversight and mitigation of risks from cybersecurity threats. Our cybersecurity risk assessment and management processes are implemented and maintained by certain Company management, including Mr. Gharib, who oversees enterprise risk management and information security for the Company. Mr. Gharib is responsible for hiring information security personnel, integrating cybersecurity risk considerations into the Company’s overall risk management strategy, and communicating key priorities to relevant personnel. Mr. Gharib is also responsible for approving budgets, helping prepare for cybersecurity incidents, approving cybersecurity processes, and reviewing security assessments and other security-related reports. Our incident response and vulnerability management processes and policies are designed to escalate certain cybersecurity incidents to members of management depending on the circumstances, including Mr. Gharib and the Chief Executive Officer. Mr. Gharib works with the Company’s incident response team to help the Company mitigate and remediate cybersecurity incidents of which they are notified. In addition, the Company’s incident response and vulnerability management processes and policies include reporting to the audit committee of the board of directors for certain cybersecurity incidents. The audit committee receives periodic reports from Mr. Gharib concerning the Company’s significant cybersecurity threats and risk and the processes the Company has implemented to address them. The audit committee also receives various reports, summaries or presentations related to cybersecurity threats, risk and mitigation.
Cybersecurity Risk Management Processes Integrated [Flag]	true
Cybersecurity Risk Management Processes Integrated [Text Block]	Our assessment and management of material risks from cybersecurity threats are integrated into the Company’s overall risk management processes. For example, cybersecurity risk is addressed as a component of the Company’s enterprise risk management program and the information technology function works with management to prioritize our risk management processes and mitigate cybersecurity threats that are more likely to lead to a material impact to our business. Additionally, Mr. Gharib and the audit committee of the board of directors evaluate material risks from cybersecurity threats against our overall business objectives and reports to the board of directors, which evaluates our overall enterprise risk.
Cybersecurity Risk Management Third Party Engaged [Flag]	true
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]	true
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]	false
Cybersecurity Risk Board of Directors Oversight [Text Block]	Our board of directors addresses the Company’s cybersecurity risk management as part of its general oversight function. The audit committee of the board of directors is responsible for overseeing Company’s cybersecurity risk management processes, including oversight and mitigation of risks from cybersecurity threats. Our cybersecurity risk assessment and management processes are implemented and maintained by certain Company management, including Mr. Gharib, who oversees enterprise risk management and information security for the Company. Mr. Gharib is responsible for hiring information security personnel, integrating cybersecurity risk considerations into the Company’s overall risk management strategy, and communicating key priorities to relevant personnel. Mr. Gharib is also responsible for approving budgets, helping prepare for cybersecurity incidents, approving cybersecurity processes, and reviewing security assessments and other security-related reports. Our incident response and vulnerability management processes and policies are designed to escalate certain cybersecurity incidents to members of management depending on the circumstances, including Mr. Gharib and the Chief Executive Officer. Mr. Gharib works with the Company’s incident response team to help the Company mitigate and remediate cybersecurity incidents of which they are notified. In addition, the Company’s incident response and vulnerability management processes and policies include reporting to the audit committee of the board of directors for certain cybersecurity incidents. The audit committee receives periodic reports from Mr. Gharib concerning the Company’s significant cybersecurity threats and risk and the processes the Company has implemented to address them. The audit committee also receives various reports, summaries or presentations related to cybersecurity threats, risk and mitigation.
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]	The audit committee of the board of directors is responsible for overseeing Company’s cybersecurity risk management processes, including oversight and mitigation of risks from cybersecurity threats.
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]	In addition, the Company’s incident response and vulnerability management processes and policies include reporting to the audit committee of the board of directors for certain cybersecurity incidents. The audit committee receives periodic reports from Mr. Gharib concerning the Company’s significant cybersecurity threats and risk and the processes the Company has implemented to address them. The audit committee also receives various reports, summaries or presentations related to cybersecurity threats, risk and mitigation.
Cybersecurity Risk Role of Management [Text Block]	We have implemented and maintain various information security processes designed to identify, assess and manage material risks from cybersecurity threats to our critical computer networks, third party hosted services, communications systems, hardware and software, and our critical data, including intellectual property, confidential information that is proprietary, strategic or competitive in nature, and personal health information (including clinical trial data) (“Information Systems and Data”). Our information technology function, which is led by Samir Gharib, our President, Chief Financial Officer, and Chief Compliance Officer, helps identify, assess and manage the Company’s cybersecurity threats and risks. Our information technology function works to identify and assess risks from cybersecurity threats by monitoring and evaluating our threat environment and the Company’s risk profile using various methods including, employing both automated and manual tools and controls; conducting threat and vulnerability assessments; utilizing third-party services to monitor our information technology infrastructure; and performing internal audits. Depending on the environment, we implement and maintain various technical, physical, and organizational measures, processes, standards and policies designed to manage and mitigate material risks from cybersecurity threats to our Information Systems and Data, including, for example: risk assessments, incident detection and response policies, network security controls for certain systems (including as applicable data segregation, data encryption, access controls, physical security, and systems threat monitoring), disaster recovery and business continuity plans, vendor risk management program, and dedicated cybersecurity staff and employee training.
Cybersecurity Risk Management Positions or Committees Responsible [Flag]	true
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]	Mr. Gharib works with the Company’s incident response team to help the Company mitigate and remediate cybersecurity incidents of which they are notified.
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]	Our incident response and vulnerability management processes and policies are designed to escalate certain cybersecurity incidents to members of management depending on the circumstances, including Mr. Gharib and the Chief Executive Officer. Mr. Gharib works with the Company’s incident response team to help the Company mitigate and remediate cybersecurity incidents of which they are notified. In addition, the Company’s incident response and vulnerability management processes and policies include reporting to the audit committee of the board of directors for certain cybersecurity incidents.
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]	true

STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	Dec. 31, 2025	Dec. 31, 2024
Cash flows from operating activities
Net loss	$ (38,966)	$ (53,036)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	2,574	5,348
Depreciation and amortization	21	46
Non-cash lease expense	268	247
Loss on disposal of property and equipment	0	2
Change in fair value of warrant liability	3,500	0
Changes in operating assets and liabilities:
Prepaid expenses and other current assets	2,447	391
Other assets	0	494
Accounts payable	(352)	(2,037)
Accrued expenses and other current liabilities	(2,502)	(2,271)
Deferred revenue	0	(4,911)
Other liabilities	(317)	(237)
Net cash used in operating activities	(33,327)	(55,964)
Cash flows from financing activities
Proceeds from issuance of common stock and warrants	50,000	0
Proceeds from issuance of common stock related to employee stock purchase plan	25	66
Proceeds from exercise of pre-funded warrants	40	0
Proceeds from exercise of common stock options	5	180
Payment of debt and equity offering costs	(3,701)	0
Repayment of term loan	(2,057)	(1,622)
Tax withholding payments on restricted stock units	(831)	(246)
Net cash provided by (used in) financing activities	43,481	(1,622)
Net increase (decrease) in cash, cash equivalents, and restricted cash	10,154	(57,586)
Cash, cash equivalents, and restricted cash at beginning of period	38,788	96,374
Cash, cash equivalents, and restricted cash at end of period	48,942	38,788
Reconciliation of cash, cash equivalents, and restricted cash
Cash and cash equivalents	48,906	38,753
Restricted cash, long-term (included in other assets)	36	35
Total cash, cash equivalents, and restricted cash	48,942	38,788
Supplemental cash flow data:
Cash paid for interest on term loan	68	225
Supplemental disclosure of non-cash investing and financing activities:
Deferred offering costs included in accrued expenses and other current liabilities	$ 82	$ 0

STATEMENTS OF STOCKHOLDERS' EQUITY (Parenthetical) $ in Thousands	12 Months Ended
	Dec. 31, 2025 USD ($)
Statement of Stockholders' Equity [Abstract]
Offering costs	$ 3,400

BALANCE SHEETS (Parenthetical) - $ / shares	Dec. 31, 2025	Dec. 31, 2024
Preferred Stock, Par Value	$ 0.0001	$ 0.0001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value	$ 0.0001	$ 0.0001
Common stock, shares authorized	200,000,000	200,000,000
Common stock, shares sold and issued	1,372,043	563,042
Common stock, shares outstanding	1,372,043	563,042

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2025

Accounting Policies [Abstract]

Schedule of Useful Lives of Property and Equipment

The useful lives of property and equipment are as follows:


Computer and office equipment	3 years
Computer software	3 years
Furniture and fixtures	5 years
Manufacturing machinery and equipment	7 years

Subsequent Events

12 Months Ended

Dec. 31, 2025

Subsequent Events [Abstract]

Subsequent Events

15. Subsequent Events

Loan Agreement with Avenue Capital

On January 7, 2026 (the “Closing Date”), the Company entered into a Loan and Security Agreement (the “Loan and Security Agreement”) and a Supplement to the Loan and Security Agreement (together with the Loan and Security Agreement, the “Loan Agreement”), with Avenue Capital Management II, L.P., as administrative agent and collateral agent (the “Agent”) and Avenue Venture Opportunities Fund II, L.P., as lender (the “Lender”, together with Agent, “Avenue Capital”). As of the date hereof, $15.0 million has been funded under the Loan Agreement.

The Loan Agreement makes available to the Company term loans in an aggregate principal amount of up to $50.0 million with (i) $15.0 million funded within 5 business days after the Closing Date (“Tranche 1”), (ii) up to $10.0 million to be made available to the Company between March 1, 2026 and September 30, 2026, subject to, among other things, the Company’s achievement of a key regulatory milestone related to the Company’s development of TA-ERT for the treatment of MPS IIIB (“Tranche 2”) and (iii) up to $15.0 million to be made available to the Company between September 1, 2026 and March 31, 2027, subject to, among other things, the Company’s achievement of an additional key regulatory milestone with respect to the Company’s development of TA-ERT for the treatment of MPS IIIB (“Tranche 3”). The Lender may make additional term loans of up to an additional $10.0 million (the “Discretionary Tranche 4” and collectively with Tranche 1, Tranche 2 and Tranche 3, the “Loans”), to be funded between October 1, 2027 and June 30, 2028, subject to, among other things, (i) the Company’s achievement of a certain commercial milestone and (ii) the mutual written agreement of the Company and the Lender (upon the Lender’s investment committee approval). The Loans bear interest at an annual rate equal to the greater of (x) the sum of 5.25% plus the prime rate as reported in The Wall Street Journal and (y) 12.25%. The Loans are secured by a lien upon and security interest in all of the Company’s assets, including intellectual property, subject to agreed exceptions. The maturity date of the Loans is July 1, 2029 (the “Maturity Date”). The Loan Agreement does not contain any minimum cash requirement or other financial covenants.

The Company will make interest only payments on the Loans until the 12-month anniversary of the Closing Date, subject to (i) a 6-month extension, so long as at least $5.0 million from Tranche 2 has been funded and (ii) an additional 12-month extension if the Company achieves the Tranche 3 milestone. The Loan principal is repayable in equal monthly installments from the end of interest only period to the Maturity Date.

The Company may, at its option at any time, prepay the Loans in their entirety by paying the then-outstanding principal balance and all accrued and unpaid interest on the Loans, subject to a prepayment fee equal to (i) 3.0% of the principal amount outstanding if the prepayment occurs on or prior to the first anniversary following the Closing Date, (ii) 2.0% of the principal amount outstanding if the prepayment occurs after the first anniversary following the

Closing Date, but on or prior to the second anniversary following the Closing Date, and (iii) 1.0% of the principal amount outstanding if the prepayment occurs after the second anniversary following the Closing Date. The Company will pay a final payment of 4.00% of the aggregate commitment amounts for Tranche 1, Tranche 2 and Tranche 3, which shall be increased to include the commitment amount of Discretionary Tranche 4 upon the funding of such tranche, on the earlier of (x) the Maturity Date and (y) the date that the Company prepays all of the outstanding principal amount of the Loans in full. On the Closing Date, the Company paid the Lender a commitment fee of $0.4 million.

The Loan Agreement contains customary representations, warranties and covenants, including covenants by the Company limiting, among other things, additional indebtedness, liens, guaranties, mergers and consolidations, substantial asset sales, investments and loans, certain corporate changes, transactions with affiliates and fundamental changes. The Loan Agreement provides for events of default customary for term loans of this type, including but not limited to non-payment, breaches or defaults in the performance of covenants, insolvency, bankruptcy and the occurrence of a material adverse effect on the Company. After the occurrence of an event of default, the Agent may (i) accelerate payment of all obligations, impose an increased rate of interest, and terminate the Lender’s commitments under the Loan Agreement and (ii) exercise any other right or remedy provided by contract or applicable law including a foreclosure on our assets.

Pursuant to the Loan Agreement, upon and following the filing of this Annual Report, the Lender will have the right to convert up to $4.0 million of the outstanding principal of the Loans (the “Conversion Option”) at a price per share equal to 120% of the exercise price of the 2026 Warrant (further discussed below), subject to certain terms and conditions, including beneficial ownership limitations.

In addition, subject to applicable law, the Lender may participate in certain equity financing transactions of the Company in an aggregate amount of up to $1.0 million on the same terms, conditions and pricing offered by the Company to other investors participating in such financing transaction (such right, the “Participation Right”). The Participation Right terminates upon the earlier of the Maturity Date and the repayment in full of all of the obligations under the Loan Agreement.

Warrant

In connection with the Loans, the Company will issue to the Lender a warrant (the “2026 Warrant”) to purchase up to $3.2 million worth of shares of the Company’s common stock upon the filing of this Annual Report. The 2026 Warrant will expire on January 31, 2031 (the “Expiration Date”) and is anticipated to have an exercise price per share equal the lower of (i) the 5-day daily volume-weighted average price of common stock, determined for the five (5) consecutive trading days immediately preceding the date of issuance, (ii) the 5-day daily volume-weighted average price of common stock, determined for the five (5) consecutive trading days prior to December 3, 2025 or (iii) the price per share of the Company’s next bona fide round of equity financing before June 30, 2026 for the purposes of raising capital, provided that any exercise of such 2026 Warrant is subject to certain beneficial ownership limitations. In addition, upon a change of control, the Lender is entitled to receive the shares of the Company's common stock underlying the 2026 Warrant without payment of the exercise price. In the event a change of control occurs prior to the issuance of the 2026 Warrant, the Company will pay Lender a success fee of $6.4 million in lieu of issuing the 2026 Warrant (the “Success Fee”). The obligation to pay the Lender the Success Fee shall terminate upon the issuance of the 2026 Warrant.

The Lender may exercise the 2026 Warrant at any time, or from time to time up to and including the Expiration Date, by making a cash payment equal to the exercise price multiplied by the quantity of shares. The Lender may also exercise the 2026 Warrant on a cashless basis by receiving a net number of shares calculated pursuant to the formula set forth in the 2026 Warrant. The 2026 Warrant will be subject to anti-dilution adjustments for stock dividends, stock splits, and reverse stock splits.

Commitments and Contingencies

12 Months Ended

Dec. 31, 2025

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

7. Commitments and Contingencies

From time to time, the Company may have certain contingent liabilities that arise in the ordinary course of business. The Company evaluates the likelihood of an unfavorable outcome in legal or regulatory proceedings to which it is a party and records a loss contingency on an undiscounted basis when it is probable that a liability has been incurred and the amount of the loss can be reasonably estimated. These judgments are subjective and based on the status of such legal proceedings, the merits of the Company’s defenses, and consultation with legal counsel. Actual outcomes of these legal proceedings may differ materially from the Company’s estimates. The Company estimates accruals for legal expenses when incurred as of each balance sheet date based on the facts and circumstances known to the Company at that time.

See Note 8 for discussion over commitments associated with the Company's license and purchase agreements.

Legal Matters

The Company’s industry is characterized by frequent claims and litigation, including claims regarding intellectual property. As a result, the Company may be subject to various legal proceedings from time to time. The results of any future litigation cannot be predicted with certainty, and regardless of the outcome, litigation can have an adverse impact on the Company because of defense and settlement costs, diversion of management resources and other factors. Other than as disclosed below, the Company was not subject to any material legal proceedings during the years ended December 31, 2025 and 2024 and management is not aware of any pending or threatened litigation that, individually or in the aggregate, could have a material adverse effect on the Company's business, financial condition or results of operations.

In January 2025, Neurocrine Biosciences, Inc. (“Neurocrine”) initiated proceedings seeking to invalidate European Patent 3,784,233 (the “Patent”) in the United Kingdom Patents Court (“UKPC”), and in August 2025, initiated similar proceeds before the Unified Patent Court (collectively, the “Patent Proceedings”). In February 2026, the UKPC issued a judgment ordering the Company to pay Neurocrine an interim payment of approximately $1.2

million for its legal costs. As of the year ended December 31, 2025, the Company accrued $1.9 million for loss contingencies associated with the Patent Proceedings which is included in accrued expenses and other current liabilities on the balance sheet and in general and administrative expenses on the statement of operations and comprehensive loss

Summary of Significant Accounting Policies (Policies)

12 Months Ended

Dec. 31, 2025

Accounting Policies [Abstract]

Basis of Presentation

Use of Estimates

Risks and Uncertainties

Concentration of Credit Risk

Segment Reporting

Cash and Cash Equivalents

Restricted Cash

Fair Value of Financial Instruments

The Company determined the fair value of financial assets and liabilities using the fair value hierarchy that describes three levels of inputs that may be used to measure fair value, as follows:

▪

Level 1—Quoted prices in active markets for identical assets and liabilities;

▪

Level 3—Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities.

Leases

Property and Equipment, Net

The useful lives of property and equipment are as follows:


Computer and office equipment	3 years
Computer software	3 years
Furniture and fixtures	5 years
Manufacturing machinery and equipment	7 years

Long-Lived Assets

Accrued Research and Development Expenses

Revenue Recognition

Research and Development Expenses

Stock-Based Compensation

▪

Expected Volatility. The expected volatility is based on the historical volatility of the Company's stock.

▪

Risk-Free Interest Rate. The risk-free interest rate is based on U.S. Treasury constant maturity rates with remaining terms similar to the expected term of the options.

▪

Forfeitures. The Company accounts for forfeitures as they occur.

The fair value of RSUs, including RSUs subject to performance-based vesting conditions, is based on the fair value of the Company's stock price on the grant-date.

Income Taxes

Comprehensive Loss

Comprehensive loss is equal to net loss as there are no components of other comprehensive loss.

Net Loss per Share

Recently Accounting Pronouncements Adopted

Recent Accounting Pronouncements Adopted

Recent Accounting Pronouncements - Not Yet Adopted

STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Deficit
Balance at Dec. 31, 2023	$ 76,509		$ 273,741	$ (197,232)
Balance, Shares at Dec. 31, 2023		547,019
Exercise of common stock options	180		180
Exercise of common stock options, Shares		1,595
Issuance of common stock related to employee stock purchase plan	66		66
Issuance of common stock related to employee stock purchase plan, Shares		2,107
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings	(246)		(246)
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings, Shares		12,321
Stock-based compensation	5,348		5,348
Net loss	(53,036)			(53,036)
Balance at Dec. 31, 2024	$ 28,821		279,089	(250,268)
Balance, Shares at Dec. 31, 2024	563,042	563,042
Exercise of common stock options	$ 5		5
Exercise of common stock options, Shares		61
Issuance of common stock related to employee stock purchase plan	25		25
Issuance of common stock related to employee stock purchase plan, Shares		5,485
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings	(831)		(831)
Issuance of common stock related to vesting of restricted stock units, net of tax withholdings, Shares		14,175
Issuance of common stock, net of offering costs	46,600		46,600
Issuance of common stock, net of offering costs, shares		502,181
Exercise of pre-funded warrants	4,288		4,288
Exercise of pre-funded warrants, Shares		287,099
Stock-based compensation	2,574		2,574
Net loss	(38,966)			(38,966)
Balance at Dec. 31, 2025	$ 42,516		$ 331,750	$ (289,234)
Balance, Shares at Dec. 31, 2025	1,372,043	1,372,043

Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2025

Summary of Stock Option Activity

A summary of the Company’s stock option activity and related information is as follows (in thousands, except share and per share amounts):


	Outstanding Stock Options			Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Life (Years)		Aggregate Intrinsic Value
Balance as of December 31, 2024		46,122		$	244.42		6.7	$	—
Granted		6,200		$	52.56
Exercised		(61	)	$	88.50
Forfeited		(9,840	)	$	122.58
Balance as of December 31, 2025		42,421		$	244.86		5.9	$	264
Vested and expected to vest as of December 31, 2025		42,421		$	244.86		5.9	$	264
Vested and exercisable as of December 31, 2025		36,295		$	273.46		5.3	$	108

Summary of RSU Activity

A summary of the Company’s RSU activity and related information is as follows (in thousands, except share and per share amounts):


	Number of RSUs			Weight-Average Grant Date Fair Value
Balance as of December 31, 2024		29,863		$	108.12
Granted		45,306		$	85.35
Vested		(22,300	)	$	82.89
Forfeited		(5,669	)	$	198.41
Balance as of December 31, 2025		47,200		$	87.33

For the years ended December 31, 2025 and 2024, the weighted-average fair value of RSUs granted was $85.35 and $119.27 per share, respectively.

Summary of Stock-Based Compensation Expense Related to Stock Options, RSUs and ESPP

The following table summarizes stock-based compensation expense related to stock options, RSUs and ESPP that is included in the Company’s statements of operations and comprehensive loss (in thousands):


	Year Ended December 31,
	2025			2024
Research and development	$	(72	)	$	2,013
General and administrative		2,646			3,335
Total stock-based compensation expense	$	2,574		$	5,348

2020 Employee Stock Purchase Plan

Schedule of Weighted-Average Assumptions to Estimate Fair Value of Stock Options and Purchase Rights Under ESPP Using the Black-Scholes Option-Pricing Model

The Company estimated the fair value of stock options and purchase rights under ESPP using the Black-Scholes option-pricing model, with the following weighted-average assumptions:


	2025						2024
	Options			ESPP			Options			ESPP
Expected term (in years)		5.3			1.4			5.5			1.4
Expected volatility		159.3	%		154.0	%		118.1	%		222.8	%
Risk-free interest rate		3.8	%		4.1	%		4.5	%		5.1	%
Expected dividend rate		0.0	%		0.0	%		0.0	%		0.0	%

Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2025	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2018
Income Tax Disclosure [Line Items]
Income tax expense	$ 0	$ 0
Increase in net valuation allowance	(14,600,000)	18,200,000
Unrecognized tax benefits	775,000	4,348,000	$ 3,240,000
Income tax penalties or interest	0	$ 0
General Business Tax Credit Carryforward
Income Tax Disclosure [Line Items]
Tax credit carryforward, amount	34,200,000
Research and Development Tax Credit Carry Forwards
Income Tax Disclosure [Line Items]
Deferred tax assets, tax credit written off	1,800,000
Orphan Drug Credits Carryforwards
Income Tax Disclosure [Line Items]
Deferred tax assets, tax credit written off	33,300,000
Federal
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	$ 163,100,000			$ 155,900,000
Net operating loss carryforwards expiration year	2036
Federal \| General Business Tax Credit Carryforward
Income Tax Disclosure [Line Items]
Tax credit carryforward expiration year	2036
State
Income Tax Disclosure [Line Items]
Net operating loss carryforwards	$ 150,000,000
Net operating loss carryforwards expiration year	2036
State \| Research and Development Tax Credit Carry Forwards
Income Tax Disclosure [Line Items]
Tax credit carryforward, amount	$ 2,800,000

Stock-Based Compensation

12 Months Ended

Dec. 31, 2025

Share-Based Payment Arrangement [Abstract]

Stock-Based Compensation

10. Stock-Based Compensation

Equity Incentive Plans

The Company adopted the 2020 Equity Incentive Plan (the “2020 Plan”) in October 2020. The 2020 Plan provides for the granting of stock options, stock appreciation rights, restricted stock, restricted stock units, and other stock or cash-based awards to individuals who are then employees, officers, directors or consultants. The number of shares of common stock available for issuance under the 2020 Plan will be automatically increased on the first day of each calendar year during the ten-year term of the 2020 Plan, beginning with January 1, 2021 and ending with January 1, 2030, by an amount equal to 5% of the outstanding number of shares of the Company’s common stock on December 31st of the preceding calendar year or such lesser amount as determined by the Company’s Board of Directors. As of December 31, 2025, 19,715 shares remained available for issuance under the 2020 Plan. On January 1, 2026, shares available for issuance under the 2020 Plan were automatically increased by 68,602 shares.

Under the 2020 Plan, individuals can be granted the ability to early exercise their options. As of December 31, 2025, there were no shares subject to repurchase by the Company related to the early exercise of options.

A summary of the Company’s stock option activity and related information is as follows (in thousands, except share and per share amounts):


	Outstanding Stock Options			Weighted- Average Exercise Price		Weighted- Average Remaining Contractual Life (Years)		Aggregate Intrinsic Value
Balance as of December 31, 2024		46,122		$	244.42		6.7	$	—
Granted		6,200		$	52.56
Exercised		(61	)	$	88.50
Forfeited		(9,840	)	$	122.58
Balance as of December 31, 2025		42,421		$	244.86		5.9	$	264
Vested and expected to vest as of December 31, 2025		42,421		$	244.86		5.9	$	264
Vested and exercisable as of December 31, 2025		36,295		$	273.46		5.3	$	108

For the years ended December 31, 2025 and 2024, the weighted-average fair value of options granted was $50.72 and $48.06 per share, respectively.

The aggregate intrinsic values of options outstanding and exercisable were calculated as the difference between the exercise price of the options and the fair value of the Company’s common stock as of the respective balance sheet date. The total intrinsic value of options exercised was immaterial and $0.3 million for the years ended December 31, 2025 and 2024, respectively. The total fair value of options vested was $9.3 million and $2.1 million for the years ended December 31, 2025 and 2024, respectively.

Restricted Stock Units (“RSUs”)

A summary of the Company’s RSU activity and related information is as follows (in thousands, except share and per share amounts):


	Number of RSUs			Weight-Average Grant Date Fair Value
Balance as of December 31, 2024		29,863		$	108.12
Granted		45,306		$	85.35
Vested		(22,300	)	$	82.89
Forfeited		(5,669	)	$	198.41
Balance as of December 31, 2025		47,200		$	87.33

For the years ended December 31, 2025 and 2024, the weighted-average fair value of RSUs granted was $85.35 and $119.27 per share, respectively.

The total fair value of RSUs vested was $1.8 million and $2.8 million for the years ended December 31, 2025 and 2024, respectively.

Performance-Based RSUs

As of December 31, 2025, the Company had 2,970 RSUs outstanding subject to performance-based vesting conditions, of which none are considered probable of achievement.

Employee Stock Purchase Plan

The Company adopted the 2020 Employee Stock Purchase Plan (the “ESPP”) in October 2020. The ESPP allows eligible employees to purchase shares of the Company’s common stock at a discount through payroll deductions of up to 15% of their eligible compensation. At the end of each purchase period, employees are able to purchase shares at 85% of the lower of the fair market value of the Company’s common stock as of the offering date or the applicable purchase date. The number of shares of common stock available for issuance under the ESPP will be automatically increased on the first day of each calendar year during the first ten-years of the term of the ESPP, beginning with January 1, 2021 and ending with January 1, 2030, by an amount equal to the lessor of (i) 1% of the outstanding number of shares of the Company’s common stock on December 31st of the preceding calendar year, (ii) 5,883 shares of common stock or (iii) such lesser amount as determined by the Board of Directors. As of December 31, 2025, 12,531 shares of common stock remained available for issuance under the ESPP. On January 1, 2026, shares available for issuance under the ESPP were automatically increased by 5,883 shares.

Except for the initial offering period, the ESPP provides for 24-month offering periods starting every January 1st and July 1st, each consisting of four six-month purchase periods.

Stock-Based Compensation Expense

The Company estimated the fair value of stock options and purchase rights under ESPP using the Black-Scholes option-pricing model, with the following weighted-average assumptions:


	2025						2024
	Options			ESPP			Options			ESPP
Expected term (in years)		5.3			1.4			5.5			1.4
Expected volatility		159.3	%		154.0	%		118.1	%		222.8	%
Risk-free interest rate		3.8	%		4.1	%		4.5	%		5.1	%
Expected dividend rate		0.0	%		0.0	%		0.0	%		0.0	%


	Year Ended December 31,
	2025			2024
Research and development	$	(72	)	$	2,013
General and administrative		2,646			3,335
Total stock-based compensation expense	$	2,574		$	5,348

As of December 31, 2025, there was approximately $3.5 million of total unrecognized stock-based compensation expense related to awards that are expected to vest, which is expected to be recognized over an estimated weighted-average vesting term of 1.8 years.